STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
msrAPutative peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (186 aa)    
Predicted Functional Partners:
msrB
Conserved hypothetical peptide methionine sulfoxide reductase. Homology to msrB of S. elongatus of 64%. Peptide methionine sulphoxide reductase reverses the inactivation of many proteins due to the oxidation of critical methionine residues by reducing methionine sulphoxide, Met(O), to methionine. InterPro: Domain of unknown function DUF25 (IPR002579). Pfam: Domain of unknown function DUF25. Tigrfam: TIGR00357: PilB-related protein. no TMHs; Family membership.
 
 0.995
helX
Putative thiol:disulfide oxidoreductase. Homology to helX of R. casulata of 35% Periplasmic protein thiol:disulphide oxidoreductase is involved in the biogenesis of c-type cytochromes as well as in disulphide bond formation in some periplasmic proteins. Tigrfam: dsbE: periplasmic protein thiol:disulfide signal peptide no TMHs; High confidence in function and specificity.
   
 0.922
azo0866
Hypothetical thioredoxin. Homology with BPP3919 of B. parapertussis of 38%. Participates in various redox reactions through the reversible oxidation of the active center dithiol to a disulfide. Tigrfam: dsbE: periplasmic protein thiol:disulfi signal peptide probable 1 TMHs; Family membership.
   
 0.922
azo2154
Conserved hypothetical secreted protein. 33% similarity to TrEMBL Q8XQF8 PROBABLE SIGNAL PEPTIDE PROTEIN [RS05314] [Ralstonia solanacearum (Pseudomonas solanacearum)]. No domains predicted. Signal P reporting signal peptide present. No TMH reported being present; Conserved hypothetical protein.
   
 0.922
mauD
Probable methylamine utilization protein. My be specifically involved in the processing transport and/or maturation of the methylamine dehydrogenase beta-subunit. Tigrfam: dsbE: periplasmic protein thiol:disulfide Signal peptide probable 1 TMHs; Family membership.
   
 0.922
trxA2
Putative thioredoxin-disulfide reductase. Homology to trxA (ECs4714) of E. coli of 27%. Participates in various redox reactions through the reversible oxidation of the active center dithiol to a dislufide. InterPro: Thioredoxin (IPR006662) no TMHs; Family membership.
   
 0.922
ccmG
Probable thiol disulfide interchange protein. Involved in disulfide bond formation. Catalyzes a late reductive step in the assembly of periplasmic c-type cytochromes probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity). InterPro: Periplasmic protein thiol:disulfide oxidoreductase DsbE (IPR004799) Interpro: Thioredoxin (IPR006662) Tigrfam: dsbE: periplasmic protein thiol:disulfide axidoreductase, DsbE superfamily signal peptide Probable 1 TMH; Family membership.
   
 0.922
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.915
cutA2
Putative protein disulfide-isomerase; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily.
   
 
 0.895
azo1635
Thioredoxin-disulfide reductase; Conserved hypothetical thioredoxin. Homology to a putative thioredoxin of N. menigitidis (NMA0966) of 50%. Participates in various redox reactions through the reversible oxidation of the active center dithiol to a disulfide. no signal peptide no TMHs; Function unclear.
   
 
 0.821
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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