STRING protein interaction network
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
hisFImidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (252 aa)    
Predicted Functional Partners:
Hisi protein; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, HisA. Similar to sprot|HIS4_RALSO (76%) and to sprot|HIS4_AZOBR (52%). Proteins involved in steps 4 and 6 of the histidine biosynthesis pathway are contained in one family. These enzymes are called His6 and His7 in eukaryotes and HisA and HisF in prokaryotes. HisA is a phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, involved in the fourth step of histidine biosynthesis. TIGRFAM (TIGR00007): [...]
Histidine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF
Hisb protein; Imidazoleglycerol-phosphate dehydratase is the enzyme that catalyzes the seventh step in the biosynthesis of histidine in bacteria, fungi and plants. Similar to sprot|HIS7_RALSO (73%) and to sprot|HI7B_ARATH (54%)and to sprot|HIS7_ECOLI (47%). Pfam: IGPD, Imidazoleglycerol-phosphate dehydratase; Specificity unclear
Phosphoribosyl-ATP pyrophosphatase, catalyzes the second step in the histidine biosynthetic pathway: 5-phosphoribosyl-ATP + H2O = 5-phosphoribosyl-AMP + PPi Similar to sprot|HIS2_PSEAE (51%) and to sprot|HIS2_AZOBR (43%). Pfam: PRA-PH, Phosphoribosyl-ATP pyrophosphohydrolase; High confidence in function and specificity
Hisd protein; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Hisg protein; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
Bifunctional purine biosynthesis protein purH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC (AICAR transformylase); IMP cyclohydrolase (EC (Inosinicase) (IMP synthetase) (ATIC)] InterPro: AICARFT/IMPCHase bienzyme; High confidence in function and specificity
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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