STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
azo3351ATP-binding cassette (ABC) transporters form a large family of proteins responsible for translocation of a variety of compounds across biological membranes. They are composed of two transmembrane domains responsible for binding and transport and two nucleotide-binding domains responsible for coupling the energy of ATP hydrolysis to conformational changes in the TMDs, TREMBL:O59091 (37% identity); TREMBL:Q7NDM5 (40% identity). Pfam (PF00005): ABC transporter. TC (3.A.1): The ATP-binding Cassette (ABC) Superfamily; High confidence in function and specificity. (301 aa)    
Predicted Functional Partners:
azo3353
Conserved hypothetical membrane protein; In Myxococcus xanthus pilI are co-transcribed with pilH an ABC transporter homologue required for type IV pilus biogenesis and social gliding. pilI appear to be functionally related to pilH. Similar to membrane protein of Geobacter sulfurreducens PCA (14%) and weak; Conserved hypothetical protein.
 
 0.967
azo3352
Similar to hypothetical protein GSU1500 of Geobacter sulfurreducens PCA (16%). TMHMM2 reporting one TMhelix. Sigcleave reporting one SignalPeptide. Coils2 reporting coiled coil region.
 
     0.875
azo1127
ATP-binding cassette (ABC) transporters are multidomain membrane proteins, responsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. ATP binding domains are responsible for coupling the energy of ATP hydrolysis to conformational changes in the ransmembrane domains. Similar to trembl|Q7W058 (49%) and to sprot|LIVG_ECOLI (39%). Pfam (PF00005): ABC transporter Smart (SM00382): AAA ATPase superfamily; Specificity unclear.
 
  
 
0.777
ampD2
N-acetyl-anhydromuramyl-L-alanine amidase; Putative signaling protein in beta-lactamase regulation. AMPD seems not to act as a direct sensor for beta-lactams. It hydrolyzes 16-anhydro-N-acetylmuramoyl-L-alanyl-D-3glutamyl-meso- diaminopimelic acid to the tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate (By similarity), TREMBL:Q8KRJ4 (63% identity); SWISSPROT:P82974 (60% identity). Pfam (PF01510): N-acetylmuramoyl-L-alanine amidase; High confidence in function and specificity.
     
 0.769
nosY
Membrane protein nosY precursor.INVOLVED IN COPPER PROCESSING. Part of the ABC transporter complex nosDFY involved in copper import. Probably responsible for the translocation of the substrate across the membrane. 43% Similar to the copper permease protein, nosY in P.stutzeri. TREMBL:Q9F0W1 InterPro:IPR001117; Cu-oxidase. SignalP: present. Number of predicted TMHs:6; High confidence in function and specificity.
  
 0.757
cbiO
Putative cobalt transport system ATP-binding protein; Part of the ABC transporter complex cbiKMQO involved in cobalt import. Probably responsible for the translocation of the substrate across the membrane. 40% AAA_ATPase.IPR003439; ABC_transporter. Pfam:PF00005; ABC_tran; 1. ProDom; PD000006; ABC_transporter; 1. SMART; SM00382; AAA; 1; High confidence in function and specificity.
  
  
 
0.752
azo0813
ABC-2 type transporter permease protein; Similar to TREMBL:Q8XV76 (69% identity); TREMBL:Q7P0X7 (66% identity); TREMBL:Q82SG1 (64% identity). InterPro (IPR000412): ABC transporter, family 2. Pfam (PF01061): ABC-2 type transporter. TMHMM reporting seven transmembrane helices. TC (3.A.1): The ATP-binding Cassette (ABC) Superfamily; Specificity unclear.
 
 
 0.750
glnQ2
Probable glutamine transport ATP-binding protein. Homology with glnQ of B. stearothermophilus of 53% (sprot|GLNQ_BACST). PART OF THE BINDING-PROTEIN-DEPENDENT TRANSPORT SYSTEM FOR GLUTAMINE. PROBABLY RESPONSIBLE FOR ENERGY COUPLING TO THE TRANSPORT SYSTEM. InterPro: AAA ATPase superfamily (IPR003593), ABC_Transporter (IPR003439), ATP/GTP_binding site motif A (P-loop) (IPR001687) Pfam: ABC transporter no signal peptide no TMHs mobB: molybdopterin-guanine dinucleotid; High confidence in function and specificity.
 
  
 
0.742
modC2
Putative molybdate transport system ATP-binding protein; 39% AAA_ATPase superfamily. IPR003439; ABC_transporter. IPR008995; MOP_like:molybdenum-pterin binding domain.IPR005116; TOBE. Pfam:PF00005; ABC_tran; 1.PF03459; TOBE; 1; High confidence in function and specificity.
 
  
 
0.731
azo1236
ATP-binding cassette (ABC) transporters form a large family of proteins responsible for translocation of a variety of compounds across biological membranes. They are composed of two transmembrane domains responsible for binding and transport and two nucleotide-binding domains responsible for coupling the energy of ATP hydrolysis to conformational changes in the TMDs. Similar to TREMBL:Q88H94 (52% identity); TREMBL:Q9RXZ1 (29% identity); SWISSPROT:Q9WYC4 (25% identity). Pfam (PF00664): ABC transporter transmembrane region. Pfam (PF00005): ABC transporter. TMHMM reporting six transmembra [...]
  
 
 0.723
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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