STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glxR1Putative 2-hydroxy-3-oxopropionate reductase Homology to glxR of E. coli of 39% (SWISSPROT:GLXR_ECOLI) Activity:- (R)-glycerate + NAD(P)(+) = 2-hydroxy-3-oxopropanoate + NAD(P)H. InterPro: 3-hydroyisobutyrate dehydrogenase (IPR002204) Pfam: Nad binding domain of 6-phosphoglucanate dehydrogenase (PF03446) Tigrfam: gnd_rel: 6-phosphoglucante no signal peptide no TMHs; Family membership. (296 aa)    
Predicted Functional Partners:
gip
Hydroxypyruvate isomerase (EC 5.3.1.22).Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).Belongs to the hyi family. 52%; High confidence in function and specificity.
 
 0.947
glxR2
Probable 2-hydroxy-3-oxopropionate reductase Homology to glxR of E. coli of 46% (SWISSPROT:GLXR_ECOLI) Activity:- (R)-glycerate + NAD(P)(+) = 2-hydroxy-3-oxopropanoate + NAD(P)H. InterPro: 3-hydroyisobutyrate dehydrogenase (IPR002204) Pfam: Nad binding domain of 6-phosphoglucanate dehydrogenase (PF03446) Tigrfam: gnd_rel: 6-phosphoglucante no signal peptide no TMHs 0; High confidence in function and specificity.
 
  
 
0.930
ttuD
Putative hydroxypyruvate reductase. Degrades an unidentified toxic product from the first step of tartrate degradation. Involved in the second step of the tartrate degradation pathway. 59% MOFRL.IPR005346; UPF0125. Pfam:PF05161; MOFRL; 1.PF03658; UPF0125; 1. Signal peptide present; High confidence in function and specificity.
    
 0.865
azo1661
Conserved hypothetical protein. Homology to cv3676 of C. violaceum of 47% (trembl|Q7NRV4). InterPro: DUF184 (IPR003781). Pfam: CoA binding domain; Acetyltransferase (GNAT) family. No signal peptide. No TMHs.
    
  0.684
azo0826
Glycerate dehydrogenase (EC 1.1.1.29) (NADH-dependent hydroxypyruvate reductase) (HPR) (GDH) (Hydroxypyruvate dehydrogenase) (Glyoxylate reductase) (HPR-A). PLAYS A CENTRAL ROLE IN ASSIMILATION OF CARBON. IT CONVERTS HYDROXYPYRUVATE TO GLYCERATE AS A KEY STEP IN THE SERINE CYCLE AND MAY ALSO PLAY AN IMPORTANT ROLE IN C2 REACTIONS BY INTERCONVERTING GLYOXYLATE AND GLYCOLATE; Specificity unclear.
    
 0.652
fadB1
Probable enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase; Alpha-subunit of fatty acid oxidation complex. Entry name TREMBL:Q8G968 Prim. accession # Q8G968 Identities = 373/642 (58%) InterPro IPR006108; 3HCDH_C. IPR006176; 3HCDH_N. Prediction: Non-secretory protein Signal peptide probability: 0.000 Number of predicted TMHs: 0 IPR008927; 6DGDH_C_like. IPR001753; EnCoA_hydrtse. Pfam PF00725; 3HCDH; 1. PF02737; 3HCDH_N; 1. PF00378; ECH; 1; Family membership.
  
 
 0.610
fadB2
Short-chain enoyl-CoA hydratase activity. Activity:- 3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O Entry name TREMBL:Q8P986 Prim. accession # Q8P986 InterPro IPR006108; 3HCDH_C. IPR006176; 3HCDH_N. IPR008927; 6DGDH_C_like. IPR001753; EnCoA_hydrtse. IPR000205; NAD_BS. Pfam PF00725; 3HCDH; 1. PF02737; 3HCDH_N; 1. PF00378; ECH; 1. Identities = 468/796 (58%) Prediction: Signal peptide Signal peptide probability: 0.980 Number of predicted TMHs: 0; Family membership.
  
 
 0.610
sigZ
Putative RNA polymerase sigma factor sigZ. The sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released. Similar to SWISSPROT: sprot|SIGZ_BACSU (23% Bacillus subtilis, RNA polymerase sigma factor SigZ) / sprot|RPSH_PSEAE (28% Pseudomonas aeruginosa, RNA polymerase sigma-h factor (sigma-30), AlgU or AlgT) InterPro: IPR000838 Sigma70_ECF. Pfam: PF07638 ECF sigma factor; High confidence in function and specificity.
  
 
 0.586
pcaC
Carboxymuconolactone decarboxylase family protein,65% Identity (78% similarity) to TrEMBL;Q8EKK9. Has PF02627, Carboxymuconolactone decarboxylase family; IPR003779, CMD: Carboxymuconolactone decarboxylase (CMD)is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins (e.g. O67982) CMD represents the C-terminal domain, Abhydrolase_1 represents the N-terminal domain; High confidence in function and specificity.
  
 
  0.570
azo0480
Conserved hypothetical irons-sulfur binding oxidase. Homology to cv4235 of C. violaceum of 70% (trembl|Q7NQA5) Pfam: FAD binding domain; FAD linked oxidase, Cterminal domain Tigrfam: glcD: glycolate oxidase subunit GlcD no signal peptide no TMHs; Family membership.
    
  0.563
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.