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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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[Homology]
Score
azo3377Conserved hypothetical protein. Homology to Bcep18194_A5800 of Burkholderia sp. 383 of 53%. Pfam: CbiX. The function of CbiX is uncertain, however it is found in cobalamin biosynthesis operons and so may have a related function. Some CbiX proteins contain a striking histidine-rich region at their C-terminus, which suggests that it might be involved in metal chelation. No signal peptide. No TMHs. (130 aa)    
Predicted Functional Partners:
cobA2
Uroporphyrin-III C-methyltransferase (Urogen III methylase) (SUMT) (Uroporphyrinogen III methylase) (UROM). TIGRFAM: dph5: diphthine synthase; High confidence in function and specificity; Belongs to the precorrin methyltransferase family.
  
 
 0.985
cbiX
CbiX conserved hypothetical protein. Function unknown. Cobalamin biosynthesis pathway; Function unclear.
  
  
  0.921
cbiL
Precorrin-2 C20-methyltransferase (EC 2.1.1.130) (S-adenosyl-L- methionine:precorrin-2 methyltransferase) (SP2MT). METHYLATES PRECORRIN-2 AT THE C-20 POSITION TO PRODUCE PRECORRIN-3A; High confidence in function and specificity.
 
  
 0.916
cbiE
Precorrin-6Y C(5,15)-methyltransferase (decarboxylating); Precorrin-6 methyltransferase (Precorrin-6Y methylase). CATALYZES THE METHYLATION OF BOTH C-5 AND C-15 IN PRECORRIN-6Y TO FORM PRECORRIN-8X. InterPro: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; High confidence in function and specificity.
 
  
 0.907
azo3378
HesA/MoeB/ThiF family protein; Region start changed from 3713308 to 3713122 (-186 bases).
       0.783
cobA1
Uroporphyrin-III C-methyltransferase (EC 2.1.1.107) (Urogen III methylase) (SUMT) (Uroporphyrinogen III methylase) (UROM). CATALYZES BOTH METHYLATIONS AT C-2 AND C-7 OF UROGEN III LEADING TO PRECORRIN-1 AND PRECORRIN-2; THEIR OXIDATIVE ESTERIFICATION GIVES RESPECTIVELY FACTOR I OCTAMETHYL ESTER AND SIROHYDROCHLORIN (BY SIMILARITY). dph5: diphthine synthase; High confidence in function and specificity.
  
 
 0.663
azo3376
Membrane fusion protein; HlyD family secretion protein. The secretion of a number of proteins/molecules require the help of members belonging to the ABC transporter family and a membrane fusion protein belonging to the HlyD family. SignalP predicting signal peptide. TC (2.A.6.1): The Heavy Metal Efflux (HME) Family; Family membership.
       0.633
azo3374
Thiosulfate sulfurtransferase; Homolog to the hypothetical protein ygaP from E.coli. SWISSPROT:YGAP_ECOLI InterPro: IPR001763; Rhodanese-like. Pfam: PF00581; Rhodanese; 1. TMhelix:2 present; Function unclear.
       0.632
azo3375
RND efflux transporter, permease protein; AcrB/AcrD/AcrF family. Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer, TREMBL:Q8KAV4 (43% identity); SWISSPROT:P25197 (23% identity). InterPro (IPR001036): Acriflavin resistance protein. PFam (PF00873): AcrB/AcrD/AcrF family. TIGRFAM (TIGR00914): Heavy metal efflux pump, CzcA family. TIGRFAM (TIGR00915): Hydrophobe/Amphiphile Efflux-1 (HAE1) Family protein. TMHMM [...]
       0.631
azo3529
Probable Precorrin-4 C11-methyltransferase,47% Identity to TrEMBL;Q8GDX1, O26702. SwissProt;O87696. Has PF00590, Tetrapyrrole (Corrin/Porphyrin) Methylases;IPR000878 Cor/por_Metransf; This family uses S-AdoMet in the methylation of diverse substrates. This family includes a related group of bacterial proteins of unknown function, including P45528. This family includes the methylase Dipthine synthase. Uroporphyrin-III C-methyltransferase (EC: 2.1.1.107) (SUMT)catalyzes the transfer of two methyl groups from S-adenosyl-L-methionine to the C-2 and C-7 atoms of uroporphyrinogen III to yiel [...]
 
   
 0.617
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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