STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
azo3445ABC transporter permease protein; Branched-chain amino acid transport system typically composed of a periplasmic substrate-binding protein, one or two reciprocally homologous integral inner-membrane proteins and one or two peripheral membrane ATP-binding proteins that couple energy to the active transport system.The integral inner-membrane proteins translocate the substrate across the membrane. Similar to trembl|Q881A7 (65%) and to sprot|LIVH_ECOLI (26%). Pfam (PF02653): Binding-system dependent bacterial transporters (araH, livH/limM families) TMHMM reporting eight Tmhelix. SignalP re [...] (308 aa)    
Predicted Functional Partners:
livM4
Putative branched-chain amino acid transport permease. Homology to livM of E. coli of 27%. Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane. Pfam: Branched-chain amino acid transport system no signal peptide probalbe 10 TMHs; Specificity unclear.
 
 0.997
azo3446
ATP-binding cassette (ABC) transporters are multidomain membrane proteins, responsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. ATP-binding protein is for coupling the energy of ATP hydrolysis to conformational changes in the transmembrane domains. Similar to trembl|Q881A6 (55%), to sprot|BRAF_PSEAE (34%) and to sprot|LIVG_ECOLI (33%). Pfam (PF00005): ABC transporter Smart (SM00382): AAA ATPase superfamily ProSite (PS50101): ATP/GTP-binding site motif A (P-loop); Specificity unclear.
 
 
 0.983
azo3443
Conserved hypothetical ABC-type branched-chain amino acid transport systems, periplasmic component. Homology to Raeut03002728 of R. eutropha of 58% (gi|45519901|ref|ZP_00171452.1|(NCBI ENTREZ)). Pfam: Receptor family ligand binding region. This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure. Signal peptide present. TMH in signal peptide; Family membership.
 
 
  0.928
livF
ATP-binding cassette (ABC) transporters are multidomain membrane proteins, responsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. ATP-binding protein is for coupling the energy of ATP hydrolysis to conformational changes in the transmembrane domains. Similar to trembl|Q7WQU7 (73%) and to trembl|Q89HM3 (54%). Pfam (PF00005): ABC transporter Smart (SM00382): AAA ATPase superfamily ProSite (PS50101): ATP/GTP-binding site motif A (P-loop); Specificity unclear.
 
 
 0.927
livM6
Putative branched-chain amino acid transporter permease. Homology to livM of E. coli of 32%. Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane. InterPro: Binding-system dependent bacterial transporters (araH livH/limM families) Pfam: Branched-chain amino acid transport system. signal peptide probable 10 TMHs; Specificity unclear.
 
 0.922
livG2
ABC transporter ATP-binding protein; Probable high-affinity branched-chain amino acid transport ATP-binding protein BraF. ATP-binding cassette (ABC) transporters are multidomain membrane proteins,responsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. ATP-binding protein is for coupling the energy of ATP hydrolysis to conformational changes in the transmembrane domains. BraF is a COMPONENT OF THE HIGH AFFINITY LEUCINE ISOLEUCINE VALINE TRANSPORT SYSTEM (LIV-I) WHICH IS OPERATIVE WITHOUT NA(+) AND IS SPECIFIC FOR ALANINE AND THREONINE IN AD [...]
 
 
 0.907
acS2
Putative Acetyl-coenzyme A synthetase; Function:-Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates cheY, the response regulator involved in flagellar movement and chemotaxis. Activity:- ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA Entry name SWISSPROT:ACSA_ECOLI InterPro:- IPR000873; AMP-bind. Pfam:- PF00501; AMP-binding; 1. Identities = 114/506 (22%) Number of predicted TMHs: 0; Family membership.
 
    0.903
azo0313
ATP-binding cassette (ABC) transporters are multidomain membrane proteins, responsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. The integral inner-membrane proteins translocate the substrate across the membrane. ATP-binding protein is for coupling the energy of ATP hydrolysis to conformational changes in the transmembrane domains. Similar to trembl|Q8XRX5 (54%) and to trembl|Q8UFI6 (47%). Pfam: ABC transporter Pfam (PF02653): Branched-chain amino acid transport system / permease component Smart : AAA ATPase SignalP reporting Signal pept [...]
 
 
 0.900
azo1992
ATP-binding cassette (ABC) transporters are multidomain membrane proteins, responsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. The integral inner-membrane proteins translocate the substrate across the membrane. ATP-binding protein is for coupling the energy of ATP hydrolysis to conformational changes in the transmembrane domains. Similar to trembl|Q8XRX5 (52%) and to trembl|Q89CG4 (45%). Pfam (PF00005): ABC transporter Pfam (PF02653): Binding-system dependent bacterial transporters (araH, livH/limM families) Smart (SM00382): AAA ATPase [...]
 
 
 0.900
azo2502
Probable branched-chain amino acid ABC transporter,ATP binding protein,; Specificity unclear; Belongs to the binding-protein-dependent transport system permease family.
 
 
 0.900
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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