Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
thiEThiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (206 aa)    
Predicted Functional Partners:
thiD1
Phosphomethylpyrimidine kinase (EC 2.7.4.7) (HMP-phosphate kinase) (HMP-P kinase). CATALYZES THE PHOSPHORYLATION OF HMP-P TO HMP-PP. TIGRFAM: HMP-P_kinase: phosphomethylpyrimidine kinase; High confidence in function and specificity.
 
 0.999
thiD2
Phosphomethylpyrimidine kinase (HMP-phosphate kinase) (HMP-P kinase). catalyzes the phosphorylation of hmp-p to hmp-pp (by similarity) TIGRFAM: HMP-P_kinase: phosphomethylpyrimidine kinase; Specificity unclear.
 
 
 0.999
thiG
Thiamine biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 
 0.990
thiL
Thiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
  
 
 0.962
thiC
Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
 
 
 0.960
thiS
Thiamine biosynthesis protein ThiS; Putative sulfur transfer protein involved in thimanin biosynsthesis; High confidence in function and specificity.
 
 
 0.958
yjeQ
Probable GTPase; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
     
 0.882
azo2804
Adenylyltransferase, putative; Dinucleotide-utilizing enzyme involved in molybdopterin and/or thiamine biosynthesis Belongs to the hesA/moeB/thiF family, by similarity. TIGR00292: thiazole biosynthesis enzyme; High confidence in function and specificity.
 
 
 0.850
hemL
Glutamate-1-semialdehyde 2,1-aminomutase (GSA) (GSA-AT). TIGRFAM: hemL: glutamate-1-semialdehyde-21-ami; High confidence in function and specificity.
    
 0.849
rubB
RubB protein; High confidence in function and specificity.
  
    0.609
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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