proC protein (Azoarcus sp. BH72) - STRING interaction network

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proC

Probable 1-pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (274 aa)

Predicted Functional Partners:

putA

0.973

pip

0.917

azo3465

0.862

proB

0.849

proA

0.834

azo3467

0.813

yggU

0.810

azo3076

0.632

rnhA1

0.624

comA

0.597

Your Current Organism:

Azoarcus sp. BH72

NCBI taxonomy Id: 62928
Other names: A. sp. BH72

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
azo3076	proA	azo3076	azo3218	Conserved hypothetical protein. Homology to TdenA01001814 of Thiobacillus denitrificans of 40% (gi\|52006871\|ref\|ZP_00334250.1\|(NBCI ENTREZ)). Has PF01402, Ribbon-helix-helix protein, copG family; IPR002145 HTH_CopG; The structure of this protein repressor, which is the shortest reported to date and the first isolated from a plasmid, has a homodimeric ribbon-helix-helix arrangement. The helix-turn-helix-like structure is involved in dimerisation and not DNA binding as might have been expected. No TMHs. No signal peptide.	ProA protein; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.	0.577
azo3076	proB	azo3076	azo3170	Conserved hypothetical protein. Homology to TdenA01001814 of Thiobacillus denitrificans of 40% (gi\|52006871\|ref\|ZP_00334250.1\|(NBCI ENTREZ)). Has PF01402, Ribbon-helix-helix protein, copG family; IPR002145 HTH_CopG; The structure of this protein repressor, which is the shortest reported to date and the first isolated from a plasmid, has a homodimeric ribbon-helix-helix arrangement. The helix-turn-helix-like structure is involved in dimerisation and not DNA binding as might have been expected. No TMHs. No signal peptide.	Prob protein; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.	0.555
azo3076	proC	azo3076	azo3466	Conserved hypothetical protein. Homology to TdenA01001814 of Thiobacillus denitrificans of 40% (gi\|52006871\|ref\|ZP_00334250.1\|(NBCI ENTREZ)). Has PF01402, Ribbon-helix-helix protein, copG family; IPR002145 HTH_CopG; The structure of this protein repressor, which is the shortest reported to date and the first isolated from a plasmid, has a homodimeric ribbon-helix-helix arrangement. The helix-turn-helix-like structure is involved in dimerisation and not DNA binding as might have been expected. No TMHs. No signal peptide.	Probable 1-pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	0.632
azo3076	putA	azo3076	azo3753	Conserved hypothetical protein. Homology to TdenA01001814 of Thiobacillus denitrificans of 40% (gi\|52006871\|ref\|ZP_00334250.1\|(NBCI ENTREZ)). Has PF01402, Ribbon-helix-helix protein, copG family; IPR002145 HTH_CopG; The structure of this protein repressor, which is the shortest reported to date and the first isolated from a plasmid, has a homodimeric ribbon-helix-helix arrangement. The helix-turn-helix-like structure is involved in dimerisation and not DNA binding as might have been expected. No TMHs. No signal peptide.	Probable bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.	0.662
azo3465	azo3467	azo3465	azo3467	Conserved hypothetical YGGT-family protein. Homology to ne0394 of N. europae of 37% (trembl\|Q82X94). This family consists of a repeat found in conserved hypothetical integral membrane proteins. The function of this region and the proteins which possess it is unknown. InterPro: YGGT family (IPR003425). Pfam: YGGT family. no signal peptide. 5 TMHs; Conserved hypothetical protein.	Conserved hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.	0.883
azo3465	proC	azo3465	azo3466	Conserved hypothetical YGGT-family protein. Homology to ne0394 of N. europae of 37% (trembl\|Q82X94). This family consists of a repeat found in conserved hypothetical integral membrane proteins. The function of this region and the proteins which possess it is unknown. InterPro: YGGT family (IPR003425). Pfam: YGGT family. no signal peptide. 5 TMHs; Conserved hypothetical protein.	Probable 1-pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	0.862
azo3465	yggU	azo3465	azo3464	Conserved hypothetical YGGT-family protein. Homology to ne0394 of N. europae of 37% (trembl\|Q82X94). This family consists of a repeat found in conserved hypothetical integral membrane proteins. The function of this region and the proteins which possess it is unknown. InterPro: YGGT family (IPR003425). Pfam: YGGT family. no signal peptide. 5 TMHs; Conserved hypothetical protein.	Conserved hypothetical protein. Homology to vc0458 of V. clholerae of 48% (sprot:Y458_VIBCH). InterPro: DUF167 (IPR003748). Pfam: Uncharacterized ACR, YGGU family, COF1872. no signal peptide. no TMHs; Belongs to the UPF0235 family.	0.865
azo3467	azo3465	azo3467	azo3465	Conserved hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.	Conserved hypothetical YGGT-family protein. Homology to ne0394 of N. europae of 37% (trembl\|Q82X94). This family consists of a repeat found in conserved hypothetical integral membrane proteins. The function of this region and the proteins which possess it is unknown. InterPro: YGGT family (IPR003425). Pfam: YGGT family. no signal peptide. 5 TMHs; Conserved hypothetical protein.	0.883
azo3467	proC	azo3467	azo3466	Conserved hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.	Probable 1-pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	0.813
azo3467	yggU	azo3467	azo3464	Conserved hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.	Conserved hypothetical protein. Homology to vc0458 of V. clholerae of 48% (sprot:Y458_VIBCH). InterPro: DUF167 (IPR003748). Pfam: Uncharacterized ACR, YGGU family, COF1872. no signal peptide. no TMHs; Belongs to the UPF0235 family.	0.713
comA	proA	azo1512	azo3218	Putative DNA uptake/competence protein; Competence protein comA. Essential for natural transformation. Could be a transporter involved in DNA uptake. InterPro: DNA internalization-related competence protein ComEC/Rec2 function: transporter activity TREMBL:Q82SD2: 38% identity,50% similarity. InterPro:IPR001279; Blactmase-like. IPR004477; ComEC_N-term. IPR004797; ComEC_Rec2. Pfam PF03772; Competence; 1. PF00753; Lactamase_B; 1. TIGRFAMs:TIGR00360; ComEC_N-term; 1. TIGR00361; ComEC_Rec2; ComEC_Rec2: DNA internalization-relate TMHMM predicted 8 transmembrane helices; High confidence in fu [...]	ProA protein; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.	0.575
comA	proB	azo1512	azo3170	Putative DNA uptake/competence protein; Competence protein comA. Essential for natural transformation. Could be a transporter involved in DNA uptake. InterPro: DNA internalization-related competence protein ComEC/Rec2 function: transporter activity TREMBL:Q82SD2: 38% identity,50% similarity. InterPro:IPR001279; Blactmase-like. IPR004477; ComEC_N-term. IPR004797; ComEC_Rec2. Pfam PF03772; Competence; 1. PF00753; Lactamase_B; 1. TIGRFAMs:TIGR00360; ComEC_N-term; 1. TIGR00361; ComEC_Rec2; ComEC_Rec2: DNA internalization-relate TMHMM predicted 8 transmembrane helices; High confidence in fu [...]	Prob protein; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.	0.519
comA	proC	azo1512	azo3466	Putative DNA uptake/competence protein; Competence protein comA. Essential for natural transformation. Could be a transporter involved in DNA uptake. InterPro: DNA internalization-related competence protein ComEC/Rec2 function: transporter activity TREMBL:Q82SD2: 38% identity,50% similarity. InterPro:IPR001279; Blactmase-like. IPR004477; ComEC_N-term. IPR004797; ComEC_Rec2. Pfam PF03772; Competence; 1. PF00753; Lactamase_B; 1. TIGRFAMs:TIGR00360; ComEC_N-term; 1. TIGR00361; ComEC_Rec2; ComEC_Rec2: DNA internalization-relate TMHMM predicted 8 transmembrane helices; High confidence in fu [...]	Probable 1-pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	0.597
pip	proC	azo1185	azo3466	Probable proline iminopeptidase; TREMBL:Q8PC98: 42% identity, 54% similarity. Proline iminopeptidase (EC 3.4.11.5) (Prolyl aminopeptidase) (PAP). SPECIFICALLY CATALYZES THE REMOVAL OF N-TERMINAL PROLINE RESIDUES FROM PEPTIDES (BY SIMILARITY). InterPro:IPR000073; A/b_hydrolase. IPR003089; AB_hydrolase. IPR002410; Peptidase_S33. IPR005944; Pept_S33. IPR000379; Ser_estrs. Pfam PF00561; Abhydrolase_1; TIGRFAMs: TIGR01249; pro_imino_pep_1 TIGR00149: conserved hypothetical protein; Specificity unclear.	Probable 1-pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	0.917
proA	azo3076	azo3218	azo3076	ProA protein; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.	Conserved hypothetical protein. Homology to TdenA01001814 of Thiobacillus denitrificans of 40% (gi\|52006871\|ref\|ZP_00334250.1\|(NBCI ENTREZ)). Has PF01402, Ribbon-helix-helix protein, copG family; IPR002145 HTH_CopG; The structure of this protein repressor, which is the shortest reported to date and the first isolated from a plasmid, has a homodimeric ribbon-helix-helix arrangement. The helix-turn-helix-like structure is involved in dimerisation and not DNA binding as might have been expected. No TMHs. No signal peptide.	0.577
proA	comA	azo3218	azo1512	ProA protein; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.	Putative DNA uptake/competence protein; Competence protein comA. Essential for natural transformation. Could be a transporter involved in DNA uptake. InterPro: DNA internalization-related competence protein ComEC/Rec2 function: transporter activity TREMBL:Q82SD2: 38% identity,50% similarity. InterPro:IPR001279; Blactmase-like. IPR004477; ComEC_N-term. IPR004797; ComEC_Rec2. Pfam PF03772; Competence; 1. PF00753; Lactamase_B; 1. TIGRFAMs:TIGR00360; ComEC_N-term; 1. TIGR00361; ComEC_Rec2; ComEC_Rec2: DNA internalization-relate TMHMM predicted 8 transmembrane helices; High confidence in fu [...]	0.575
proA	proB	azo3218	azo3170	ProA protein; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.	Prob protein; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.	0.999
proA	proC	azo3218	azo3466	ProA protein; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.	Probable 1-pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	0.834
proA	putA	azo3218	azo3753	ProA protein; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.	Probable bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.	0.958
proB	azo3076	azo3170	azo3076	Prob protein; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.	Conserved hypothetical protein. Homology to TdenA01001814 of Thiobacillus denitrificans of 40% (gi\|52006871\|ref\|ZP_00334250.1\|(NBCI ENTREZ)). Has PF01402, Ribbon-helix-helix protein, copG family; IPR002145 HTH_CopG; The structure of this protein repressor, which is the shortest reported to date and the first isolated from a plasmid, has a homodimeric ribbon-helix-helix arrangement. The helix-turn-helix-like structure is involved in dimerisation and not DNA binding as might have been expected. No TMHs. No signal peptide.	0.555