STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo3494Conserved hypothetical membrane protein. Homology to CV0155 of Chromobacterium violaceum of 69% (trembl|Q7P1Q8). Has PF03653, Uncharacterised protein family (UPF0093);IPR005265, Cons_hypoth701:It appears the conserved hypothetical integral membrane proteins of this family are found only in gram negative bacteria and their function is unknown. No signal peptide. 4 TMHs; Conserved hypothetical protein. (136 aa)    
Predicted Functional Partners:
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.962
hemN
Oxygen-independent coproporphyrinogen III oxidase. ANAEROBIC TRANSFORMATION OF COPROPORPHYRINOGEN-III INTO PROTOPORPHYRINOGEN-IX. hemN: oxygen-independent coproporphyrinogen III oxidase; High confidence in function and specificity.
 
  
 0.947
hemF
HemF protein; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX.
 
  
 0.932
azo3495
Conserved hypothetical protein; 55%; Specificity unclear.
       0.806
azo3492
Putative sensor histidine kinase, His_kinA_N. IPR009082; His_kin_homodim. IPR003660; HAMP. IPR003594; ATPbind_ATPase. Pfam: PF02518; HATPase_c. PF00512; HisKA. PF00672; HAMP. SMART: SM00387; HATPase_c. SM00388; HisKA. SM00304; HAMP. TMHMM reporting 2 transmembrane helices; Specificity unclear.
       0.636
sasR
Probable sigma-54 dependent response regulator,AAA_ATPase. IPR008931; FIS-like. IPR002197; HTH_Fis. IPR010114; NtrC. IPR001789; Response_reg. IPR008298; Res_reg_NtrC. IPR002078; Sig54_interact. Pfam: PF02954; HTH_8. PF00072; Response_reg. PF00158; Sigma54_activat. SMART: SM00382; AAA. SM00448; REC. HTH reporting reporting nucleic acid binding motif; Family membership.
       0.636
azo1754
Conserved hypothetical membrane protein. Homology Avin02003871 of Azotobacter vinelandii of 47% (gi|53610588|ref|ZP_00089122.2|(NBCI ENTREZ)). Has PF03653, Uncharacterised protein family (UPF0093). Interpro: IPR005265; Cons_hypoth701; It appears the conserved hypothetical integral membrane proteins of this family are found only in gram negative bacteria and their function is unknown. Signal peptide. 3 TMHs; Conserved hypothetical protein.
  
  
  0.587
ascD
Probable CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase reductase. Homology to ascD of Y. pestis of 41% (sprot|ASCD_YERPE). PARTICIPATES IN THE CONVERSION OF CDP-6-DEOXY-D-GLYCERO- L-THREO-4-HEXULOSE TO 36-DIDEOXY-D-GLYCERO-D-GLYCERO-4-HEXULOSE TOGETHER WITH CDP-6-DEOXY-D-GLYCERO-L-THREO-4-HEXULOSE-3-DEHYDRASE (E1) IN TWO CONSECUTIVE STEPS. THE DETAILED MECHANISM OF E3 IS NOT YET RESOLVED. InterPro: Oxidoreductase FAD and NAD(P)-binding domain (IPR001433); NadH:cytochrome b5 reductase (CBR) (IPR000134); 2Fe-2S Ferredoxin (IPR006057); Phenol hydroylase reductase family (IPR001221) [...]
       0.569
azo3965
Coproporphyrinogen oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
    
 0.562
mobB2
Molybdopterin-guanine dinucleotide biosynthesis protein B. MAY BIND THE GUANINE NUCLEOTIDE REQUIRED FOR THE SYNTHESIS OF MOLYBDOPTERIN GUANINE DINUCLEOTIDE. InterPro: ATP/GTP-binding site motif A (P-loop) TIGRFAM: mobB: molybdopterin-guanine dinucleotide; High confidence in function and specificity.
       0.556
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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