Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ascDProbable CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase reductase. Homology to ascD of Y. pestis of 41% (sprot|ASCD_YERPE). PARTICIPATES IN THE CONVERSION OF CDP-6-DEOXY-D-GLYCERO- L-THREO-4-HEXULOSE TO 36-DIDEOXY-D-GLYCERO-D-GLYCERO-4-HEXULOSE TOGETHER WITH CDP-6-DEOXY-D-GLYCERO-L-THREO-4-HEXULOSE-3-DEHYDRASE (E1) IN TWO CONSECUTIVE STEPS. THE DETAILED MECHANISM OF E3 IS NOT YET RESOLVED. InterPro: Oxidoreductase FAD and NAD(P)-binding domain (IPR001433); NadH:cytochrome b5 reductase (CBR) (IPR000134); 2Fe-2S Ferredoxin (IPR006057); Phenol hydroylase reductase family (IPR001221) [...] (339 aa)    
Predicted Functional Partners:
hoxF
Probable hydrogen dehydrogenase, alpha subunit. Homology to hoxF of A. eutrophus of 41% (sprot|HOXF_ALCEU). SUBUNITS ALPHA AND GAMMA OF HOXS CONSTITUTE AN NADH-OXIDOREDUCTASE. InterPro: Respiratory-chain NADH dehydrogenase 51 Kd subunit (IPR001949); Respiratory-chain NADH dehydrogenase 24 Kd subunit (IPR002023) Pfam: Respiratory-chain NADH dehydrogenase 24 Kd subunit; Respiratory-chain NADH dehydrogenase 51 Kd subunit no signal peptide no TMHs; High confidence in function and specificity.
  
 0.971
fdh1B
Probable formate dehydrogenase (NADP+), beta subunit Homology to fdh1B of M. extorpuens of 55% (trembl|Q8KTI8) Pfam: Respiratory-chain NADH dehydrogenase 24 kD subunit; Respiratory-chain NADH dehydrogenase 51 kD subunit. no signal peptide no TMHs; High confidence in function and specificity.
  
 0.971
boxA
Benzoyl-CoA oxygenase component A. 84% 4Fe4S_ferredoxin. IPR001709; FPN_cyt_redctse. IPR001433; Oxred_FAD/NAD(P). Pfam:PF00037; Fer4; 2. PF00175; NAD_binding_1; 1; High confidence in function and specificity.
  
 0.966
gltD
Glutamate synthase (small chain) oxidoreductase; Glutamate synthase [NADPH] precursor (EC 1.4.1.13) (NADPH-GOGAT)small chain. TREMBL:Q8XV67-77% identity, 87% similarity InterPro:IPR006005- One pathway for the assimilation of ammonia and glutamate biosynthesis involves glutamate synthase (EC: 1.4.1.13) which transfers the amide group of glutamine to 2-oxoglutarate to yield two molecules of glutamate. 2 L-glutamate + NADP+ = L-glutamine + 2-oxoglutarate + NADPH + H+ gid: gid protein Pfam:FAD binding domain,Thi family, 4Fe-4S binding domain,KTN-NAD binding domain, DUF127; High confidence [...]
   
 0.953
pyrD
Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
  
 0.949
nifU
Probable nitrogen fixation protein NifU; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.
  
 0.946
ribAB
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
  
 
 0.923
napG
Probable ferredoxin-type protein napG. Homology to napG of E. coli of 57% (sprot|NAPG_ECOLI). Involved in electron transfer in a wide variety of metabolic reactions. InterPro: MauM/NapG family ferredoxin-type protein (IPR004494); 7 Fe ferredoxin (IPR000813); 4Fe-4S ferredoxin; iron-sulfur binding domain (IPR001450) Pfam: 4Fe-4S binding domain Tigrfam: mauM_napG: MauM/NapG family ferredoxin-type protein no signal peptide no TMHs; High confidence in function and specificity.
  
 0.903
azo0480
Conserved hypothetical irons-sulfur binding oxidase. Homology to cv4235 of C. violaceum of 70% (trembl|Q7NQA5) Pfam: FAD binding domain; FAD linked oxidase, Cterminal domain Tigrfam: glcD: glycolate oxidase subunit GlcD no signal peptide no TMHs; Family membership.
 
 0.901
putA
Probable bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.
    
 0.890
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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