Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cyt2Probable cytochrome c-552 precursor. Homology to cyt of N. europaea of 52% (AAB46987). ELECTRON DONOR FOR CYTOCHROME CD1 IN NITRITE AND NITRATE RESPIRATION. InterPro: Cytochrome c class I (IPR003088); cytochrome c,class ID (IPR002324) Pfam: cytochrome c signal peptide no TMHs; High confidence in function and specificity. (102 aa)    
Predicted Functional Partners:
msrP
Conserved hypothetical protein; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R [...]
   
 0.852
norC
Nitric-oxide reductase subunit C (EC 1.7.99.7) (Nitric oxide reductase cytochrome c subunit) (NOR small subunit).COMPONENT OF THE ANAEROBIC RESPIRATORY CHAIN THAT TRANSFORMS NITRATE TO DINITROGEN (DENITRIFICATION).54% IPR000345; CytC_heme_BS. Pfam; PF00034; Cytochrom_C; 1. SignalP: present TMHelix:1; High confidence in function and specificity.
  
 
 0.733
azo2935
Conserved hypothetical protein TMHMM2 reporting the presence of 1 TMH's. No Signal peptide present. Has 2 WD40 repeats;SMART;SM00320, Beta-transducin (G-beta) is one of the three subunits (alpha, beta, and gamma) of the guanine nucleotide-binding proteins (G proteins) which act as intermediaries in the transduction of signals generated by transmembrane receptors (see IPR001632). The alpha subunit binds to and hydrolyzes GTP; the functions of the beta and gamma subunits are less clear but they seem to be required for the replacement of GDP by GTP as well as for membrane anchoring and re [...]
  
  
 0.719
azo2969
Conserved hypothetical secreted protein. Homology to ebA582 of Azoarcus sp. EbN1 of 37% (gnl|keqq|eba:ebA582(KEGG)). No domains predicted. Signal P reporting signal peptide. No TMHs; Conserved hypothetical protein.
    
 0.695
norB
Nitric-oxide reductase subunit B (EC 1.7.99.7) (Nitric oxide reductase cytochrome b subunit). 69% similarity to the P.stutzeri NorB protein. COMPONENT OF THE ANAEROBIC RESPIRATORY CHAIN THAT TRANSFORMS NITRATE TO DINITROGEN (DENITRIFICATION). NorB IS THE CATALYTIC SUBUNIT OF THE ENZYME COMPLEX. SHOWS PROTON PUMP ACTIVITY ACROSS THE MEMBRANE IN DENITRIFYING BACTERIAL CELLS. THE MONONITROGEN REDUCTION IS PROBABLY COUPLED TO ELECTRON TRANSPORT PHOSPHORYLATION.Belongs to the heme-copper respiratory oxidase family. Swiss Prot: Q59647. IPR000883; COX1. PF00115; COX1; 1. TMHMM:predicted trans [...]
  
 
 0.686
coxB
Conserved hypothetical cytochrome c oxidase,subunit II; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
  
 
 0.683
nosRb
Conserved hypothetical transcriptional activator for nitrous-oxide reductase, C-termial domain. Homology to nosr (C-terminal domain) of Azoarcus sp. EbN1 of 74% (gnl|keqq|eba:ebB224(KEGG)). no domains predicted. no signal peptide. probable 3 TMHs; Conserved hypothetical protein.
  
  
 0.630
nosRa
Transcriptional activator for nitrous-oxide reductase, N-terminal domain; Regulatory protein nosR. Transcriptional activation of the nitrous-oxide reductase gene nosZ. Similar to SWISSPROT: sprot|NOSR_PSEST (37% Pseudomonas stutzeri (Pseudomonas perfectomarina), regulatory protein NosR). TMHMM reporting 5 transmembrane helices. HTH reporting nucleic acid binding motif; High confidence in function and specificity.
  
  
 0.630
nosZ
Nitrous-oxide reductase. Homology to nosZ of a. eutrophus of 78% (sprot|NOSZ_ALCEU) Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity). no domains probable signal peptide no TMHs met_pdase_I: methionine aminopeptidas; High confidence in function and specificity.
  
  
 0.630
azo2510
Putative iron-sulfur protein; Bacterial ring hydroxylating dioxygenase,small subunit. Similar to AlcE: iron-sulfur-containing dioxygenases, probably involved in alcaligin biosynthesis pathway in Bordetella species. Putative iron-sulfure protein involved in aromatic compounds degradations. Rieske [2Fe-2S] domain present. Probable Choline monooxygenase chloroplast precursor (EC 1.14.15.7). nadp_idh_euk: isocitrate dehydrogenase; Function unclear.
  
     0.628
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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