STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ureFProbable urease accessory protein UreF; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter. (234 aa)    
Predicted Functional Partners:
ureE
Probable urease accessory protein UreE; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family.
  
 0.998
ureG
Urease accessory protein UreG; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
 
 
 0.996
ureD
Putative urease accessory protein UreD; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
 
 
 0.996
ureC
Urease alpha subunit. Homology to ureC of S. meliloti of 75% (sprot|URE1_RHIME). Urease (urea amidohydrolase, EC: 3.5.1.5) catalyses the hydrolysis of urea to form ammonia and carbamate. The enzyme consists of three structural domains: an alpha subunit (with the C-terminal two-thirds representing the catalytic domain), a beta subunit and a gamma subunit. Pfam: Urease alpha-subunit, catalytic domain; Urease alpha-subunit N-terminal domain no signal peptide no TMHs; High confidence in function and specificity.
 
 
 0.994
ureA
Urease gamma subunit. Homology to ureA of S. meliloti of 71% (sprot|URE3_RHIME) Urease (urea amidohydrolase, EC: 3.5.1.5) catalyses the hydrolysis of urea to form ammonia and carbamate. The enzyme consists of three structural domains: an alpha subunit (with the C-terminal two-thirds representing the catalytic domain), a beta subunit and a gamma subunit. InterPro: Urease gamma subunit (IPR002026) Pfam: urease, gamma subunit Tigrfam: urease_gam: urease gamma subunit no signal peptide no TMHs; High confidence in function and specificity.
 
 
 0.988
ureB
Probable urease beta subunit; Region start changed from 3848352 to 3848310 (-42 bases); Belongs to the urease beta subunit family.
 
 
 0.984
hypB
Probable hydrogenase accessory protein HypB. Homology to hypB of E. coli of 56% (sprot|HYPB_ECOLI). IS REQUIRED FOR THE FORMATION OF HYDROGENASE ISOENZYMES. AFFECTS SOME ASPECT OF THE PROCESSING OF HYDROGENASES and NICKEL INCORPORATION scince HYPB GENE LESIONS CAN BE COMPLEMENTED BY HIGH NICKEL ION CONCENTRATION IN THE MEDIUM. Pfam: HypB/UreG nucleotide-binding domain Tigrfam: hypB: hydrogenase accessory protein Hyp no signal peptide no TMHs; High confidence in function and specificity.
  
 
 0.975
urtD
Conserved hypothetical ABC transporter, ATP binding protein. Homology to pp4844 of P. putida of 70% (trembl|Q88DI1). Probable component of a branched-chain amino-acid transport system. Pfam: ABC-Transporter no signal peptide no TMHs; Family membership.
 
   
 0.590
azo3506
Conserved hypothetical protein. Homology to Daro03003730 of Dechloromonas aromatica of 40% (gi|46140350|ref|ZP_00203571.1|(NBCI ENTREZ)). no domains predicted. no signal peptide. no TMHs; Family membership.
       0.531
urtC
Probable ABC transporter, membrane spanning protein. Homology to urtC of Anabaena sp. of 41% (involved in urea transport). Part of the binding-protein-dependent transport system. Probably responsible for the translocation of the substrates across the membrane. InterPro: Binding-system dependent bacterial transporters (araH livH/limM families) Pfam: Branched-chain amino acid transport system signal peptide probable 9 TMHs; Function unclear.
 
   
 0.517
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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