Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
wrbA3Probable tryptophan repressor binding protein (flavodoxin); Flavoprotein wrbA3. TREMBL:Q8PGA8: 53% identity,66% similarity. wrbA3 is 26% identical to wrbA1 and 23% identical to wrbA2 InterPro: IPR008254; Flav_nitox_synth. IPR001226; Flavodoxin. Pfam:PF00258: flavodoxin; TIGR00301: NADP oxidoreductase coenzyme Number of transmembrane helices:0; High confidence in function and specificity. (184 aa)    
Predicted Functional Partners:
ubiE1
Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2).
     
  0.578
ubiE2
Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2).
     
  0.578
azo3770
Conserved hypothetical protein, 43% identity (60% similarity) to TrEMBL; Q8ZML9. TrEMBL;Q8X937(44% identity to Escherichia coli) Has PF04972, Putative phospholipid-binding domain;IPR007055, TAD; This domain is found in a family of osmotic shock protection proteins (e.g. P27291). It is also found in some Secretins and a group of potential haemolysins. Its likely function is attachment to phospholipid membranes. Has SMART;SM00257,LysM, Lysin motif:IPR002482; This domain is about 40 residues long and is found in a variety of enzymes involved in bacterial cell wall degradation. This domain [...]
   
  
 0.572
azo3515
Putative transcriptional regulatory protein,; Conserved hypothetical protein.
       0.562
prkA
Putative serine protein kinase. Homology to prkA of Bacillus subtilis of 32% (gnl|keqq|bsu:BG10804). Pfam: PrkA serine kinase. This is a family of PrkA bacterial and archaeal serine kinases approximately 630 residues long. PrkA possesses the A-motif of nucleotide-binding proteins and exhibits distant homology to eukaryotic protein kinases. Note that many family members are hypothetical. Interpro: IPR010650 PrkA serine kinase. No signal peptide. No TMHs.,; Family membership.
   
    0.553
azo1752
Conserved hypothetical secreted protein: Homology to ne0129 of N. europaea of 43% (trembl|Q82XW6). Smart: Bacterial OsmY and nodulation domain (BON). The BON domain is typically ~60 residues long and has an alpha/beta predicted fold. There is a conserved glycine residue and several hydrophobic regions. This pattern of conservation is more suggestive of a binding or structural function rather than a catalytic function. Most proteobacteria seem to possess one or two BON-containing proteins, typically of the OsmY-type proteins. signal peptide. no TMHs; Conserved hypothetical protein.
  
    0.505
nqo1
NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Quinone reductase 1) (QR1) (DT-diaphorase) (DTD) (Azoreductase) (Phylloquinone reductase) (Menadione reductase). The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis (By similarity). trembl:Q9I4B4:72%identity; 81% similarity InterPro: NAD(P)H dehydrogenase (quinone) InterPro:IPR003680; NADHdh_2. Pfam:PF02525; Flavo [...]
 
  
 0.490
azo0098
Conseved hypothetical membrane protein. Homology to RSO2271 of R. solanacearum of 36% (trembl|Q8Y3B1(SRS)). Pfam: Lysin motif (SM00257) This domain is about 40 residues long and is found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. No signal peptide 1 TMH; Conserved hypothetical protein.
   
  
 0.482
azo2990
Putative isochorismatase; Similar to TREMBL:Q88PY7 (90% identity); SWISSPROT:P21367 (87% identity); TREMBL:Q7W0U0 (85% identity). InterPro (IPR000868): Isochorismatase hydrolase. Pfam (PF00857): Isochorismatase family; Specificity unclear.
   
    0.465
azo1764
Conserved hypothetical secreted protein. Homology to bb3588 of B. bronchiseptica of 41% (trembl|Q7WGK1). Smart: Bacterial OsmY and nodulation domain (BON). The BON domain is typically ~60 residues long and has an alpha/beta predicted fold. There is a conserved glycine residue and several hydrophobic regions. This pattern of conservation is more suggestive of a binding or structural function rather than a catalytic function. Most proteobacteria seem to possess one or two BON-containing proteins, typically of the OsmY-type proteins. signal peptide. TMH in signal peptide; Conserved hypoth [...]
   
    0.426
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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