STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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cobBCobyrinic acid AC-diamide synthase. Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine and one molecule of ATP is hydrogenolyzed for each amidation (By similarity). cbiA: cobyrinic acid ac-diamide synthase; High confidence in function and specificity. (431 aa)    
Predicted Functional Partners:
cbiC
Precorrin-8X methylmutase. CATALYZES THE CONVERSION OF PRECORRIN-8X TO HYDROGENOBYRINIC ACID; A Cobalamin biosynthesis precorrin isomerase. METHYL MIGRATION REACTION DURING THE TRANSFORMATION OF PRECORRIN-3 TO FORM COBYRINIC ACID (BY SIMILARITY). InterPro: Precorrin-8X methylmutase CbiC/CobH TIGRFAM: redox_disulf_1: redox-active disulfide; High confidence in function and specificity.
 
 0.996
cobO
Cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.
 
 
 0.996
azo3529
Probable Precorrin-4 C11-methyltransferase,47% Identity to TrEMBL;Q8GDX1, O26702. SwissProt;O87696. Has PF00590, Tetrapyrrole (Corrin/Porphyrin) Methylases;IPR000878 Cor/por_Metransf; This family uses S-AdoMet in the methylation of diverse substrates. This family includes a related group of bacterial proteins of unknown function, including P45528. This family includes the methylase Dipthine synthase. Uroporphyrin-III C-methyltransferase (EC: 2.1.1.107) (SUMT)catalyzes the transfer of two methyl groups from S-adenosyl-L-methionine to the C-2 and C-7 atoms of uroporphyrinogen III to yiel [...]
 
 
 0.984
cobQ
Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
  
 0.957
azo2630
Cobalamin biosynthesis protein, putative; CobN Magnesium Chelatase family protein, by similarity; Family membership.
 
 
 0.946
cobU
Cobinamide kinase/cobinamide phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.
 
 
 0.946
azo3524
Conserved hypothetical nitroreductase. Homology to cv1555 of C. violaceum of 72% (trembl|Q7NXS1). Involved in the reduction of nitrogen containing compounds. InterPro: Nitroreductase family (IPR000415). Pfam: Nitroreductase family. no signal peptide. no TMHs; Conserved hypothetical protein.
  
 0.942
cobT
Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
  
 0.933
cbiE
Precorrin-6Y C(5,15)-methyltransferase (decarboxylating); Precorrin-6 methyltransferase (Precorrin-6Y methylase). CATALYZES THE METHYLATION OF BOTH C-5 AND C-15 IN PRECORRIN-6Y TO FORM PRECORRIN-8X. InterPro: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; High confidence in function and specificity.
  
 0.918
azo2781
Conserved hypothetical protein. Homology to ebA1022 of Azoarcus sp. EbN1 of 86% (gnl|keqq|eba:ebA1022(KEGG)). Has PF01923, Cobalamin adenosyltransferase;IPR002779,DUF80; This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation. The EutT enzyme appears to be an adenosyl transferase, converting CNB12 to AdoB12. No signal peptide or TMH present.
    
 0.912
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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