STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cobA2Uroporphyrin-III C-methyltransferase (Urogen III methylase) (SUMT) (Uroporphyrinogen III methylase) (UROM). TIGRFAM: dph5: diphthine synthase; High confidence in function and specificity; Belongs to the precorrin methyltransferase family. (297 aa)    
Predicted Functional Partners:
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.998
cbiX
CbiX conserved hypothetical protein. Function unknown. Cobalamin biosynthesis pathway; Function unclear.
 
 
 0.982
azo3377
Conserved hypothetical protein. Homology to Bcep18194_A5800 of Burkholderia sp. 383 of 53%. Pfam: CbiX. The function of CbiX is uncertain, however it is found in cobalamin biosynthesis operons and so may have a related function. Some CbiX proteins contain a striking histidine-rich region at their C-terminus, which suggests that it might be involved in metal chelation. No signal peptide. No TMHs.
  
 
 0.980
cysI
Putative sulfite reductase; 49% Fd-NiR.IPR011255; NiR_SiRalpha_1/3.IPR006067; Nir_Sir_4Fe4S.IPR005117; NiR_SiR_beta_fer. Pfam:PF01077; NIR_SIR; 2.PF03460; NIR_SIR_ferr; 2; High confidence in function and specificity.
 
  
 0.974
hemB
Porphobilinogen synthase; Delta-aminolevulinic acid dehydratase chloroplast precursor (ALADH) (ALAD). InterPro: Delta-aminolevulinic acid dehydratase; High confidence in function and specificity; Belongs to the ALAD family.
 
 
 0.972
hemD
HemD protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 0.970
cysH
Probable phosphoadenylyl-sulfate reductase; Reduction of activated sulfate into sulfite.
 
  
 0.948
hemL
Glutamate-1-semialdehyde 2,1-aminomutase (GSA) (GSA-AT). TIGRFAM: hemL: glutamate-1-semialdehyde-21-ami; High confidence in function and specificity.
 
  
 0.937
cysD
Putative sulfate adenylyltransferase subunit 2; 84% PAPS_reduct. Pfam:PF01507; PAPS_reduct; 1; High confidence in function and specificity.
 
  
 0.934
cbiL
Precorrin-2 C20-methyltransferase (EC 2.1.1.130) (S-adenosyl-L- methionine:precorrin-2 methyltransferase) (SP2MT). METHYLATES PRECORRIN-2 AT THE C-20 POSITION TO PRODUCE PRECORRIN-3A; High confidence in function and specificity.
 
  
 0.934
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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