| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| azo2781 | azo3553 | azo2781 | azo3553 | Conserved hypothetical protein. Homology to ebA1022 of Azoarcus sp. EbN1 of 86% (gnl|keqq|eba:ebA1022(KEGG)). Has PF01923, Cobalamin adenosyltransferase;IPR002779,DUF80; This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation. The EutT enzyme appears to be an adenosyl transferase, converting CNB12 to AdoB12. No signal peptide or TMH present. | Putative ABC-type transporter, ATPase component; 37% Similar to the iron(III)-hydroxamate transport membrane protein, fhuC in E.coli.Part of the ABC transporter complex fhuACDB involved in iron(III)-hydroxamate import. Probably responsible for energy coupling to the transport system. SWISSPROT:FHUC_ECOLI:P07821 InterPro:IPR003593; AAA_ATPase.IPR003439; ABC_transporter. Pfam:PF00005; ABC_tran; 1; High confidence in function and specificity. | 0.545 |
| azo2781 | cobB | azo2781 | azo3550 | Conserved hypothetical protein. Homology to ebA1022 of Azoarcus sp. EbN1 of 86% (gnl|keqq|eba:ebA1022(KEGG)). Has PF01923, Cobalamin adenosyltransferase;IPR002779,DUF80; This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation. The EutT enzyme appears to be an adenosyl transferase, converting CNB12 to AdoB12. No signal peptide or TMH present. | Cobyrinic acid AC-diamide synthase. Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine and one molecule of ATP is hydrogenolyzed for each amidation (By similarity). cbiA: cobyrinic acid ac-diamide synthase; High confidence in function and specificity. | 0.912 |
| azo2781 | cobC | azo2781 | azo3519 | Conserved hypothetical protein. Homology to ebA1022 of Azoarcus sp. EbN1 of 86% (gnl|keqq|eba:ebA1022(KEGG)). Has PF01923, Cobalamin adenosyltransferase;IPR002779,DUF80; This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation. The EutT enzyme appears to be an adenosyl transferase, converting CNB12 to AdoB12. No signal peptide or TMH present. | Cobalamin biosynthesis protein, CobC. CobC is probable involved in the conversion of cobyric acid to cobinamide.Similar to pir|B83486 (48%) and to sprot|COBC_PSEDE (42%). InterPro (PF00155): Aminotransferases class-I and II; Specificity unclear. | 0.909 |
| azo2781 | cobD1 | azo2781 | azo2173 | Conserved hypothetical protein. Homology to ebA1022 of Azoarcus sp. EbN1 of 86% (gnl|keqq|eba:ebA1022(KEGG)). Has PF01923, Cobalamin adenosyltransferase;IPR002779,DUF80; This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation. The EutT enzyme appears to be an adenosyl transferase, converting CNB12 to AdoB12. No signal peptide or TMH present. | Cobalamin biosynthesis transmembrane protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.900 |
| azo2781 | cobD2 | azo2781 | azo3518 | Conserved hypothetical protein. Homology to ebA1022 of Azoarcus sp. EbN1 of 86% (gnl|keqq|eba:ebA1022(KEGG)). Has PF01923, Cobalamin adenosyltransferase;IPR002779,DUF80; This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation. The EutT enzyme appears to be an adenosyl transferase, converting CNB12 to AdoB12. No signal peptide or TMH present. | Putative cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.900 |
| azo2781 | cobO | azo2781 | azo3552 | Conserved hypothetical protein. Homology to ebA1022 of Azoarcus sp. EbN1 of 86% (gnl|keqq|eba:ebA1022(KEGG)). Has PF01923, Cobalamin adenosyltransferase;IPR002779,DUF80; This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation. The EutT enzyme appears to be an adenosyl transferase, converting CNB12 to AdoB12. No signal peptide or TMH present. | Cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.934 |
| azo2781 | cobQ | azo2781 | azo3517 | Conserved hypothetical protein. Homology to ebA1022 of Azoarcus sp. EbN1 of 86% (gnl|keqq|eba:ebA1022(KEGG)). Has PF01923, Cobalamin adenosyltransferase;IPR002779,DUF80; This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation. The EutT enzyme appears to be an adenosyl transferase, converting CNB12 to AdoB12. No signal peptide or TMH present. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.913 |
| azo2781 | cobS | azo2781 | azo3561 | Conserved hypothetical protein. Homology to ebA1022 of Azoarcus sp. EbN1 of 86% (gnl|keqq|eba:ebA1022(KEGG)). Has PF01923, Cobalamin adenosyltransferase;IPR002779,DUF80; This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation. The EutT enzyme appears to be an adenosyl transferase, converting CNB12 to AdoB12. No signal peptide or TMH present. | Cobalamin (5'-phosphate) synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.919 |
| azo2781 | cobU | azo2781 | azo3557 | Conserved hypothetical protein. Homology to ebA1022 of Azoarcus sp. EbN1 of 86% (gnl|keqq|eba:ebA1022(KEGG)). Has PF01923, Cobalamin adenosyltransferase;IPR002779,DUF80; This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation. The EutT enzyme appears to be an adenosyl transferase, converting CNB12 to AdoB12. No signal peptide or TMH present. | Cobinamide kinase/cobinamide phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.952 |
| azo3553 | azo2781 | azo3553 | azo2781 | Putative ABC-type transporter, ATPase component; 37% Similar to the iron(III)-hydroxamate transport membrane protein, fhuC in E.coli.Part of the ABC transporter complex fhuACDB involved in iron(III)-hydroxamate import. Probably responsible for energy coupling to the transport system. SWISSPROT:FHUC_ECOLI:P07821 InterPro:IPR003593; AAA_ATPase.IPR003439; ABC_transporter. Pfam:PF00005; ABC_tran; 1; High confidence in function and specificity. | Conserved hypothetical protein. Homology to ebA1022 of Azoarcus sp. EbN1 of 86% (gnl|keqq|eba:ebA1022(KEGG)). Has PF01923, Cobalamin adenosyltransferase;IPR002779,DUF80; This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation. The EutT enzyme appears to be an adenosyl transferase, converting CNB12 to AdoB12. No signal peptide or TMH present. | 0.545 |
| azo3553 | cobA2 | azo3553 | azo3551 | Putative ABC-type transporter, ATPase component; 37% Similar to the iron(III)-hydroxamate transport membrane protein, fhuC in E.coli.Part of the ABC transporter complex fhuACDB involved in iron(III)-hydroxamate import. Probably responsible for energy coupling to the transport system. SWISSPROT:FHUC_ECOLI:P07821 InterPro:IPR003593; AAA_ATPase.IPR003439; ABC_transporter. Pfam:PF00005; ABC_tran; 1; High confidence in function and specificity. | Uroporphyrin-III C-methyltransferase (Urogen III methylase) (SUMT) (Uroporphyrinogen III methylase) (UROM). TIGRFAM: dph5: diphthine synthase; High confidence in function and specificity; Belongs to the precorrin methyltransferase family. | 0.764 |
| azo3553 | cobB | azo3553 | azo3550 | Putative ABC-type transporter, ATPase component; 37% Similar to the iron(III)-hydroxamate transport membrane protein, fhuC in E.coli.Part of the ABC transporter complex fhuACDB involved in iron(III)-hydroxamate import. Probably responsible for energy coupling to the transport system. SWISSPROT:FHUC_ECOLI:P07821 InterPro:IPR003593; AAA_ATPase.IPR003439; ABC_transporter. Pfam:PF00005; ABC_tran; 1; High confidence in function and specificity. | Cobyrinic acid AC-diamide synthase. Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine and one molecule of ATP is hydrogenolyzed for each amidation (By similarity). cbiA: cobyrinic acid ac-diamide synthase; High confidence in function and specificity. | 0.837 |
| azo3553 | cobD1 | azo3553 | azo2173 | Putative ABC-type transporter, ATPase component; 37% Similar to the iron(III)-hydroxamate transport membrane protein, fhuC in E.coli.Part of the ABC transporter complex fhuACDB involved in iron(III)-hydroxamate import. Probably responsible for energy coupling to the transport system. SWISSPROT:FHUC_ECOLI:P07821 InterPro:IPR003593; AAA_ATPase.IPR003439; ABC_transporter. Pfam:PF00005; ABC_tran; 1; High confidence in function and specificity. | Cobalamin biosynthesis transmembrane protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.539 |
| azo3553 | cobD2 | azo3553 | azo3518 | Putative ABC-type transporter, ATPase component; 37% Similar to the iron(III)-hydroxamate transport membrane protein, fhuC in E.coli.Part of the ABC transporter complex fhuACDB involved in iron(III)-hydroxamate import. Probably responsible for energy coupling to the transport system. SWISSPROT:FHUC_ECOLI:P07821 InterPro:IPR003593; AAA_ATPase.IPR003439; ABC_transporter. Pfam:PF00005; ABC_tran; 1; High confidence in function and specificity. | Putative cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.545 |
| azo3553 | cobO | azo3553 | azo3552 | Putative ABC-type transporter, ATPase component; 37% Similar to the iron(III)-hydroxamate transport membrane protein, fhuC in E.coli.Part of the ABC transporter complex fhuACDB involved in iron(III)-hydroxamate import. Probably responsible for energy coupling to the transport system. SWISSPROT:FHUC_ECOLI:P07821 InterPro:IPR003593; AAA_ATPase.IPR003439; ABC_transporter. Pfam:PF00005; ABC_tran; 1; High confidence in function and specificity. | Cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.874 |
| azo3553 | cobQ | azo3553 | azo3517 | Putative ABC-type transporter, ATPase component; 37% Similar to the iron(III)-hydroxamate transport membrane protein, fhuC in E.coli.Part of the ABC transporter complex fhuACDB involved in iron(III)-hydroxamate import. Probably responsible for energy coupling to the transport system. SWISSPROT:FHUC_ECOLI:P07821 InterPro:IPR003593; AAA_ATPase.IPR003439; ABC_transporter. Pfam:PF00005; ABC_tran; 1; High confidence in function and specificity. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.610 |
| azo3553 | cobU | azo3553 | azo3557 | Putative ABC-type transporter, ATPase component; 37% Similar to the iron(III)-hydroxamate transport membrane protein, fhuC in E.coli.Part of the ABC transporter complex fhuACDB involved in iron(III)-hydroxamate import. Probably responsible for energy coupling to the transport system. SWISSPROT:FHUC_ECOLI:P07821 InterPro:IPR003593; AAA_ATPase.IPR003439; ABC_transporter. Pfam:PF00005; ABC_tran; 1; High confidence in function and specificity. | Cobinamide kinase/cobinamide phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.640 |
| cobA2 | azo3553 | azo3551 | azo3553 | Uroporphyrin-III C-methyltransferase (Urogen III methylase) (SUMT) (Uroporphyrinogen III methylase) (UROM). TIGRFAM: dph5: diphthine synthase; High confidence in function and specificity; Belongs to the precorrin methyltransferase family. | Putative ABC-type transporter, ATPase component; 37% Similar to the iron(III)-hydroxamate transport membrane protein, fhuC in E.coli.Part of the ABC transporter complex fhuACDB involved in iron(III)-hydroxamate import. Probably responsible for energy coupling to the transport system. SWISSPROT:FHUC_ECOLI:P07821 InterPro:IPR003593; AAA_ATPase.IPR003439; ABC_transporter. Pfam:PF00005; ABC_tran; 1; High confidence in function and specificity. | 0.764 |
| cobA2 | cobB | azo3551 | azo3550 | Uroporphyrin-III C-methyltransferase (Urogen III methylase) (SUMT) (Uroporphyrinogen III methylase) (UROM). TIGRFAM: dph5: diphthine synthase; High confidence in function and specificity; Belongs to the precorrin methyltransferase family. | Cobyrinic acid AC-diamide synthase. Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine and one molecule of ATP is hydrogenolyzed for each amidation (By similarity). cbiA: cobyrinic acid ac-diamide synthase; High confidence in function and specificity. | 0.905 |
| cobA2 | cobC | azo3551 | azo3519 | Uroporphyrin-III C-methyltransferase (Urogen III methylase) (SUMT) (Uroporphyrinogen III methylase) (UROM). TIGRFAM: dph5: diphthine synthase; High confidence in function and specificity; Belongs to the precorrin methyltransferase family. | Cobalamin biosynthesis protein, CobC. CobC is probable involved in the conversion of cobyric acid to cobinamide.Similar to pir|B83486 (48%) and to sprot|COBC_PSEDE (42%). InterPro (PF00155): Aminotransferases class-I and II; Specificity unclear. | 0.492 |