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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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gene co-occurrence
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nadDNicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (227 aa)    
Predicted Functional Partners:
nadE
NAD(+) synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 
 0.976
rsfS
Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
 
  
 0.968
nadC
Nicotinate-nucleotide diphosphorylase (carboxylating); Nicotinate-nucleotide pyrophosphorylase [carboxylating] (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase). TIGRFAM: nadC: nicotinate-nucleotide pyrophosphorylase; High confidence in function and specificity; Belongs to the NadC/ModD family.
 
  
 0.955
ygaD1
Probable CinA-related protein; Hypothetical 17.2 kDa protein 1 in recA 5region. TREMBL:Q9KUH9: 54% identity, 64% similarity CinA is the first gene in the competence-inducible (cin) operon, and is thought to be specifically required at some stage in the process of transformation [1]. This is a C-terminal region of putative competence-damaged proteins from the cin operon InterPro:IPR008136; CinA_C. Pfam: PF02464; CinA cinA_cterm: competence/damage-inducible p No signal peptide. No transmembrane helices; High confidence in function and specificity.
 
 
 0.946
rlmH
Putative secreted protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family.
  
  
 0.927
ppnK
Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.916
npd2
NAD-dependent deacetylase 2 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 2). Modulates the activities of several enzymes which are inactive in their acetylated form. Similar to SWISSPROT: sprot|NPD2_PSEAE (50% Pseudomonas aeruginosa, Npd2) / sprot|NPD1_ARCFU (33% Archaeoglobus fulgidus, NpdA) InterPro: IPR003000 SIR2. Pfam: PF02146 Sir2 family; High confidence in function and specificity.
   
 0.893
pntAB
Conserved hypothetical NAD(P) transhydrogenase,subunit alpha part 2. Homology to pntA of X. axonopodis of 74% (trembl|Q8PNW6). The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. 3 TMHs no signal peptide; High confidence in function and specificity.
     
 0.882
surE
Phosphoric-monoester phosphohydrolase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
 0.881
azo1385
Conserved hypothetical protein; Predicted RNA-binding protein containing KH domain possibly ribosomal protein.
  
  
 0.865
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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