Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
adhCAlcohol dehydrogenase class III (Formaldehyde dehydrogenase (glutathione)). Homology to fdh of E. coli of 72% (trembl|Q59399) CLASS-III ADH IS REMARKABLY INEFFECTIVE IN OXIDIZING ETHANOL BUT IT READILY CATALYZES THE OXIDATION OF LONG-CHAIN PRIMARY ALOCHOLS AND THE OXIDATION OF S-(HYDROXYMETHYL) GLUTATHIONE (BY SIMILARITY). InterPro: Zinc-containing alcohol dehydrogenase superfamily (IPR002085) Zinc-containing alcohol dehydrogenase (IPR002328) Pfam: zinc-binding dehydrogenase Tigrfam: tdh: L-threonine 3-dehydrogenase. no signal peptide. 2 TMHs; High confidence in function and specificity. (370 aa)    
Predicted Functional Partners:
azo3624
Probable esterase; Serine hydrolase involved in the detoxification of formaldehyde.
 0.999
azo2700
Conserved hypothetical alcohol dehydrogenase. Homology to bp2820 of B. pertussis of 29% (TREMBL:Q7VV69). InterPro: Iron-containing alcohol dehydrogenase (IPR001670). Pfam: Iron-containing alcohol dehydrogenase. no signal peptide. no TMHs; Family membership.
    
 0.916
nagAa
Naphthalene 12-dioxygenase system ferredoxin--NAD(+) reductase component COMPONENT OF NAPHTHALENE DIOXYGENASE (NDO) MULTICOMPONENT ENZYME SYSTEM WHICH CATALYZES THE INCORPORATION OF BOTH ATOMS OF MOLECULAR OXYGEN INTO NAPHTHALENE TO FORM CIS- NAPHTHALENE DIHYDRODIOL. TRANSFERS ELECTRONS FROM FERREDOXIN (NDOA) TO NADH; High confidence in function and specificity.
  
 
 0.898
cumB
Cytidine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.
  
 
  0.809
azo1971
Putative alcohol dehydrogenase; SPROT:ADH1_BACST:31% identity; 45% similarity Alcohol dehydrogenase (EC 1.1.1.1) (ADH-T). THERMOSTABLE NAD(+)-DEPENDENT ALCOHOL DEHYDROGENASE. an alcohol + nad(+) = an aldehyde or ketone + nadh. cofactor:binds 2 zinc ions per subunit (by similarity). InterPro: IPR002328; ADH_zinc. IPR002085:Adh_zn_family. Pfam:PF00107; ADH_zinc_N tdh: L-threonine 3-dehydrogenase; Specificity unclear.
  
 
0.801
adhA
Putative Alcohol dehydrogenase. Homology to adh-HT of B. stearothermophilus (sprot|ADH3_BACST) THERMOSTABLE AND THERMOPHILIC NAD(+)-DEPENDENT ALCOHOL DEHYDROGENASE. BEARS MAINLY AN ETHANOL-DEHYDROGENASE ACTIVITY. CATALYTIC ACTIVITY:An alcohol + NAD(+) = an aldehyde or ketone + NADH. COFACTOR: Binds 2 zinc ions per subunit (By similarity). Pfam: Zinc-binding dehydrogenase Tirgfam: tdh: L-threonine 3-dehydrogenase no signal peptide no TMHs; Family membership.
    
 0.786
azo0660
ATP-binding cassette (ABC) transporters form a large family of proteins responsible for translocation of a variety of compounds across biological membranes. They are composed of two transmembrane domains responsible for binding and transport and two nucleotide-binding domains responsible for coupling the energy of ATP hydrolysis to conformational changes in the TMDs. Similar to TREMBL:Q87G83 (52% identity); TREMBL:Q9K1A3 (61% identity); SWISSPROT:Q57180 (60% identity). Pfam (PF00005): ABC transporter. TMHMM reporting five transmembrane helices. TC (3.A.1): The ATP-binding Cassette (ABC [...]
    
  0.686
azo1236
ATP-binding cassette (ABC) transporters form a large family of proteins responsible for translocation of a variety of compounds across biological membranes. They are composed of two transmembrane domains responsible for binding and transport and two nucleotide-binding domains responsible for coupling the energy of ATP hydrolysis to conformational changes in the TMDs. Similar to TREMBL:Q88H94 (52% identity); TREMBL:Q9RXZ1 (29% identity); SWISSPROT:Q9WYC4 (25% identity). Pfam (PF00664): ABC transporter transmembrane region. Pfam (PF00005): ABC transporter. TMHMM reporting six transmembra [...]
    
  0.686
msbA1
Lipid A export ATP-binding/permease protein; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
    
  0.686
azo2785
Conserved hypothetical membrane protein. Homology to SC3D11.05C of Streptomyces coelicolor of 33% (trembl|Q9L1F7(SRS)). Pfam (PF00005): ABC transporter. Pfam (PF00664): ABC transporter transmembrane region. TMHMM reporting three transmembrane helices. No signal peptide; Conserved hypothetical protein.
    
  0.686
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.