STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
pilNType 4 fimbrial biogenesis protein PilN, similarity to trembl|Q82SK2(51%)and to pir|S77727(42%). In P. aeruginosa PilN was found to be required for fimbrial biogenesis by complementation studies using twitching motility and sensitivity to fimbrial-specific phage as indicators of the presence of functional fimbriae. SignalP reporting signal peptide; Specificity unclear. (199 aa)    
Predicted Functional Partners:
pilP
Type 4 fimbrial biogenesis protein, PilP. PilP is essential for the biogenesis of type IV pili. Similar to trembl|Q7NZU1(37%). SignalP reporting Signal Peptide; Family membership.
 
 
 0.999
pilO
Type 4 fimbrial biogenesis protein PilO, similarity to pir|S77728 (40%). PilO proteins are involved in the assembly of pilin. TMHMM reporting one TMH; Specificity unclear.
 
 
 0.999
pilM
Type 4 fimbrial biogenesis protein PilM, similarity to trembl|Q82SK1 (56%)and to pir|S77726 (47%). Four genes,pilM-P, encode the necessary proteins and pilM is required for the assembly of the type IV fimbriae in Pseudomonas aeruginosa; Specificity unclear.
 
 0.999
pilQ
Type 4 fimbrial biogenesis protein PilQ, similarity to sprot|PILQ_PSEAE (41%) and trembl|Q8XV60 (45%). PilQ is essential for the biogenesis of type IV pili. Its precise function is unknown, but it has been suggested that it may act as a pilus channel in the final stages of pilus assembly. InterPro (PF00263): General (type II) secretion pathway (GSP) D protein SignalP reporting signal peptide; Specificity unclear.
 
 
 0.996
azo0098
Conseved hypothetical membrane protein. Homology to RSO2271 of R. solanacearum of 36% (trembl|Q8Y3B1(SRS)). Pfam: Lysin motif (SM00257) This domain is about 40 residues long and is found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. No signal peptide 1 TMH; Conserved hypothetical protein.
  
 
   0.950
azo2092
Conserved hypothetical membrane protein. Homology to ebA1234 of Azoarcus sp. EbN1 of 38% (gnl|keqq|eba:ebA1234(KEGG)). no domains predicted. no signal peptide. 1 TMH; Conserved hypothetical protein.
  
 
 0.938
gspD2
Protein D is involved in the type II general secretion pathway within Gram-negative bacteria, a signal sequence-dependent process responsible for protein export. The most probable location of protein D is the outer membrane. This suggests that protein D constitutes the apparatus of the accessory mechanism, and is thus involved in transporting exoproteins from the periplasm, across the outer membrane, to the extracellular environment. Similar to trembl|Q8XTG8 (39%). Pfam (PF00263): General (type II) secretion pathway (GSP) D protein Pfam (PF07660): Secretin and TonB N terminus short dom [...]
  
 
 0.913
pilE
Putative prepilin like protein; In P. aeruginosa PilE is probable involved in pilus biogenesis and in twitching motility. Similar to trembl|Q82TX3 (50%) and to pir|G82857 (43%). Pfam (PF00114): Pilin (bacterial filament) SignalP reporting Signal peptide. TMHMM reporting one Tmhelix; Function unclear.
 
  
 0.809
fimV1
Putative type 4 pilus biogenesis; In Pseudomonas aeruginosa, FimV ist probable involved in remodelling of the peptidoglycan layer to enable assembly of the type IV fimbrial structure and machinery. And it is also required for twitching motility. Similar to trembl|O87015 (28%). Pfam (PF01476): LysM domain Pfam (PF04102): SlyX, may be a coiled-coil structure SignalP reporting Signal peptide; Function unclear.
  
  
 0.798
pilZ
Type IV pilus biogenesis protein PilZ, 56% identity to TrEMBL;Q87YH3, Q8PBU4. Has PF07238, Type IV pilus assembly protein PilZ; IPR009875; This family consists of several bacterial type IV pilus assembly proteins. PilZ is thought to have a cytoplasmic location and be essential for type 4 fimbrial biogenesis but its exact function is unknown.
  
   
 0.795
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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