Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mrcAProbable penicillin-binding protein 1A (PBP-1a) (PBP1a) [Includes: Penicillin- insensitive transglycosylase (EC 2.4.2.-) (Peptidoglycan TGase); Penicillin-sensitive transpeptidase (EC 3.4.-.-) (DD-transpeptidase)]. Homology to mrcA of N. meningitides of 47% (sprot|PBPA_NEIMA(SRS)) Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) (By sim [...] (790 aa)    
Predicted Functional Partners:
pbpA
Penicillin-binding protein; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily.
  
 
0.957
FtsI
Probable peptidoglycan glycosyltransferase; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily.
  
 
0.934
mtgA
Probable monofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family.
 
 
0.923
dacC
Probable D-alanyl-D-alanine carboxypeptidase. Homology to dacD of E. coli of 41% (sprot|DACD_ECOLI) Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. Pfam: D-alanyl-D-alanine carboxypeptidase signal peptide no TMHs; High confidence in function and specificity; Belongs to the peptidase S11 family.
     
 0.897
dacB
Serine-type D-Ala-D-Ala carboxypeptidase; Penicillin-binding protein 4 precursor (PBP-4) [Includes: D-alanyl-D- alanine carboxypeptidase (EC 3.4.16.4) (DD-peptidase) (DD- carboxypeptidase); D-alanyl-D-alanine-endopeptidase (DD-endopeptidase)]. Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction. PBP4: D-alanyl-D-alanine carboxypeptid; High confidence in function and specificity.
     
 0.875
mltG
Conserved hypothetical protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.
  
   
 0.713
rodA
Rod shape-determining protein; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily.
  
   
 0.710
aroK
Probable shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
     
 0.672
murC
Probable UDP-N-acetylmuramate-L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family.
  
   
 0.666
murA
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.
  
   
 0.627
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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