STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pyrEOfficial Name Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (222 aa)    
Predicted Functional Partners:
pyrF
Orotidine-5'-phosphate decarboxylase (Orotidylic decarboxylase) (OMP decarboxylase) (OMPdcase) (Uridine 5'-monophosphate synthase) (UMP synthase); High confidence in function and specificity; Belongs to the OMP decarboxylase family. Type 2 subfamily.
 
 
 0.999
pyrD
Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
  
 0.996
pyrX
Probable dihydroorotase. Homology to pyrC' of P. putida of 44% (sprot|PYRX_PSEPU) This protein tends to appear in a large, multifunctional complex with aspartate transcarbamoylase. It is inactive but is required as a non-catalytic subunit of aspartate transcarbamoylase. InterPro: Dihydroorotase multifunctional complex type (IPR004722); Dihydroorotase (IPR002195) Tigrfam: pyrC_multi: dihydroorotase multifunctional complex type no signal peptide no TMHS; High confidence in function and specificity.
  
 
 0.960
pyrR
Phosphoribosyl transferase or bifunctional regulator/uracil phosphoribosyltransferase; High confidence in function and specificity.
  
 
 0.953
pyrB
Aspartate carbamoyltransferase (Aspartate transcarbamylase) (Carbamylaspartotranskinase) (ATCase); High confidence in function and specificity; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
  
 0.940
carA
Carbamoyl-phosphate synthase (glutamine-hydrolyzing) small chain; High confidence in function and specificity; Belongs to the CarA family.
  
  
 0.937
carB
Carbamoyl-phosphate synthase (glutamine-hydrolyzing) large chain InterPro: Carbamoyl-phosphate synthase; High confidence in function and specificity; Belongs to the CarB family.
  
 
 0.917
prsA
Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 
 0.909
azo2695
Conserved hypothetical protein. Homology to BF2580 of Bacteroides fragilis of 47% (gnl|keqq|bfr:BF2580(KEGG)). No domains predicted. No TMHs. No signal peptide.
  
 
 0.893
lapP
Phenol hydroxylase P5 protein (EC 1.14.13.7) (Phenol 2-monooxygenase P5 component). Probable electron transfer from NADPH via FAD and the 2Fe-2S center to the oxygenase activity site of the enzyme; High confidence in function and specificity.
  
 
 0.854
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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