STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
bleOPutative bleomycin resistance protein; Bleomycin (Blm) is a glycopeptide antibiotic produced naturally by actinomycetes. It is a strong DNA-cutting agent and thus finds use as a potent anti-cancer drug. Actinomycetes have developed a defence mechanism against this lethal compound, producing a protein that confers resistance to Blm through drug sequestering.Putative Bleomycin resistance protein,; Family membership. (122 aa)    
Predicted Functional Partners:
azo3712
Conserved hypothetical protein. Homology to Raeut03002407 of Ralstonia eutropha of 48% (gi|46132577|ref|ZP_00171131.2|(NBCI ENTREZ)). Pfam: NUDIX domain. No signal peptide. No TMHs.
    
  0.716
nadE
NAD(+) synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.617
argA
Amino-acid N-acetyltransferases acting mainly on glutamate in the first step of the 'acetylated' ornithine biosynthesis pathway. For this reason it is also called N-acetylglutamate synthase. The enzyme may also act on aspartate. Similar to sprot|ARGA_YERPE (44%) and to sprot|ARGA_ECOLI (43%). Pfam (PF00696): Aspartokinase superfamily Pfam (PF00583): GCN5-related N-acetyltransferase; Specificity unclear.
    
  0.568
azo3711
Conserved hypothetical protein; Similar to SWISSPROT:P39367 (68% identity),TREMBL:Q8Z1C8 (66% identity).
       0.518
azo3710
Conserved hypothetical transferase. Homology to the IAA acetyltransferase of A. brasilense of 37% (sprot|IAAT_AZOBR). The IAA acetyltransferase participates in the tryptophan-dependent indole-3-acetic acid production, which is a phytohormone released by A.brasilense. Interpro: GCN5-related N-acetyltransferase (IPR000182). Pfam: Acetyltransferase (GNAT) family. no signal peptide. no TMHs; Conserved hypothetical protein.
    
  0.461
azo2427
Conserved hypothetical membrane protein. Homology to BB1720 of Bordetella bronchiseptica of 32% (trembl|Q7WLM5). Has PF03992, Antibiotic biosynthesis monooxygenase;IPR007138;This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 (Q9X9W3) is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue. TMHMM2 reporting 2 TMH's Present. No Signal Peptide present; Conserved hypothetical protein.
  
     0.422
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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