Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
bcr2Bicyclomycin resistance protein homolog. Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase (By similarity). InterPro: General carbohydrate, amino acid, and divalent cation transport. Occurence of signal peptide and 12 transmembrane helices. Presence of DUF domains and Cation transport ATPase C-terminus domains. 35% identity and 47% similarity to bcr from X.axonopodis. Probably it is a copy of bcr1 in Azoarcus BH72 genome; Conserved hypothetical protein. (398 aa)    
Predicted Functional Partners:
azo3736
Conserved hypothetical protein. Homology to rsc0338 of R. solanacearum of 64% (trembl|Q8Y2J7). Probable Mg(2+) chelatase family protein. InterPro: Mg chelatase-related protein (IPR004482); MCM family (IPR001208); AAA ATPase superfamily (IPR003593); Magnesium chalatase, chlI subunit (IPR000523); TypeI antifreeze protein (IPR000104). no signal peptide. no TMHs. TIGR00368: Mg chelatase-related protein; Family membership.
       0.702
hylD
Putative HylD family secretion protein. Homology to hylD of E. coli of 24% (sprot|HLY4_ECOLI) Involved in the transport of hemolysin A. InterPro: HlyD family secretion protein; Gram-negative bacteril RTX secretion protein D Pfam: HylD family secretion protein no signal peptide no TMHs; Family membership.
  
 0.565
azo0835
Membrane fusion protein; The secretion of a number of proteins/molecules require the help of members belonging to the ABC transporter family and a membrane fusion protein belonging to the HlyD family,; Family membership.
  
 0.565
azo3737
Putative secreted protein; Conserved hypothetical protein. Homology to NE0192 of N.europaea of 52% (trembl:Q82XR2). Has PF04380, Protein of unknown function (DUF526);IPR007475; This is a family of uncharacterised proteins. No signal peptide. No TMHs.
       0.556
metH
Probable methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
     
  0.529
pheA
Bifunctional chorismate mutase/prephenate dehydratase P-protein, pheA,; High confidence in function and specificity.
  
 
 0.500
tolC
Putative outer membrane effluxe protein protein. Homology to tolC from E. coli of 33%. The OEP family (outer membreane effluxe protein) allow export of a variety of substrates in Gram negative bacteria. TolC is believed to be a membre af an ABC transporter system for protein secretion without cleavage of a signal sequence. Pfam: Outer membrane efflux protein Signal peptide no TMHs; Family membership.
    
 0.493
azo1783
Conserved hypothetical membrane protein. Homology to ebA6946 of Azoarcus sp. EbN1 of 64% (gnl|keqq|eba:ebA6946(KEGG)). Pfam: Pospholipase D, active site motife; DedA family. no signal peptide. 6 TMHs; Conserved hypothetical protein.
     
  0.488
pabB
Para-aminobenzoate synthase component I (EC 4.1.3.-) (ADC synthase). CATALYZES THE BIOSYNTHESIS OF 4-AMINO-4-DEOXYCHORISMATE (ADC) FROM CHORISMATE AND GLUTAMINE. InterPro: Anthranilate synthase component I and chorismate binding enzyme pabB: para-aminobenzoate synthase component I; Specificity unclear.
   
 
 0.472
azo0224
Hypotethical outer membrane efflux protein. Homology to PA2525 of P. aeruginosa of 25%. signal peptide. no TMHs.
    
 0.420
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: low (28%) [HD]