STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
darRProbable AraC family transcriptional regulator,; High confidence in function and specificity. (320 aa)    
Predicted Functional Partners:
azo3750
This is a family of hydrolase enzymes. Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoatesynthase catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate. Similar to TREMBL:Q7NWS7 (61% identity); TREMBL:Q8UIM8 (57% identity); TREMBL:Q89UX3 (33% identity). InterPro (IPR000868): Isochorismatase hydrolase. Pfam (PF00857): Isochorismatase family; Family membership.
 
    0.954
rpoD
RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
   
 
 0.707
ampR
Probable transcriptional regulator, LysR family; Probable HTH-type transcriptional activator ampR. Regulates the expression of the beta-lactamase gene. Represses cephalosporinase (ampC) in the presence of beta-lactams and induces it in the absence of them. Similar to SWISSPROT: sprot|AMPR_PSEAE (34% Pseudomonas aeruginosa,HTH-type transcriptional activator AmpR) Pfam: PF00126 Bacterial regulatory helix-turn-helix protein, lysR family. HTH reporting nucleic acid binding motif; High confidence in function and specificity.
       0.519
rpoS
Putative RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.
   
 
 0.507
rpoH
RNA polymerase sigma-32 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.
   
 
 0.507
azo0830
Putative AraC-family transcriptional regulator,; Conserved hypothetical protein.
  
   0.418
azo0495
Putative NADH dehydrogenase; 33%; Specificity unclear.
 
    0.414
azo0011
The short-chain dehydrogenases/reductases family is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases, similarity to SWISSPROT:P37959 (35% identity); TREMBL:Q930L8 (44% identity); TREMBL:Q9I3W5 (41% identity). Pfam (PF00106): Short chain dehydrogenase. InterPro (IPR002198): Short-chain dehydrogenase/reductase (SDR). InterPro (IPR002347): Glucose/ribitol dehydrogenase; Specificity unclear.
  
     0.413
lexA
Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
   
   0.410
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.