STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hupLProbable ferredoxin hydrogenase, large subunit. Homology to hoxG of A. eutrophus of 68% (>sprot|MBHL_ALCEU). This enzyme recycles the H(2) produced by nitrogenase to increase the production of ATP and to protect nitrogenase against inhibition or damage by O(2) under carbon- or phosphate-limited conditions. Pfam: Nickel dpendent hydrogenase no signal peptide no TMHs; High confidence in function and specificity. (598 aa)    
Predicted Functional Partners:
hupS
Ferredoxin hydrogenase, small subunit. Homology to hoxK of A. eutrophus of 83% (sprot:MBHS_ALCEU). This enzyme recycles the H(2) produced by nitrogenase to increase the production of ATP and to protect nitrogenase against inhibition or damage by O(2) under carbon- or phosphate-limited conditions. Tigrfam: hydA: hydrogenase (NiFe) small subunit Pfam: NADH ubiquinone oxidoreductase 20kD signal peptide no TMHs; High confidence in function and specificity.
 
 0.999
hoxB
Ferredoxin hydrogenase, small subunit. Homology to hoxB of A. hydrogenophilus of 75% (TREMBL:P94154). Hydrogenases catalyse the reversible oxidation of molecular hydrogen and play a vital role in anaerobic metabolism. InterPro: Hydrogenase (NiFe) small subunit HydA (IPR001821); Respiroatory-chain NADH dehydrogenase 20 kD subunit (IPR006137) Tigrfam: hydA: hydrogenase (NiFe) small subunit (hydA) Pfam: NADH ubiquinone oxidoreductase no signal peptide no TMHs; High confidence in function and specificity.
 
 0.998
hupC
Probable Ni/Fe-hydrogenase, B-type cytochrome subunit. Homology to hupZ of A. chroococcum of 65% (sprot|CYBH_AZOCH) Probable b-type cytochrome. InterPro: Nickel-dependent hydrogenase b-type cytochrome subunit (IPR000516) Pfam: Nickel-dependent hydrogenase b-type cytrochrome subunit no signal peptide 4 TMHs; High confidence in function and specificity.
 
 
 0.996
azo3485
Conserved hypothetical iron-sulfur binding protein. Homology to pb1470 of B. pertussis of 48% (trembl|Q7VY84). Transfer of electrons in a wide variety of metabolic reactions. InterPro: 4Fe-4S ferredoxin iron-sulfur binding domain (IPR001450). Pfam: 4Fe-4S binding domain. no signal peptide. no TMHs; Family membership.
  
 0.953
hypA
Probable hydrogenase nickel inorporation protein hypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.951
hoxY
Probable hydrogen dehydrogenase, delta subunit. Homology to hoxY of a. eutrophus of 45% (sprot|HOXY_ALCEU). InterPro: Respiratory-chain NADH dehydrogenase 20 Kd subunit Pfam: NADH ubiquinone oxidoreductase, 20 kD subunit no signal peptie no TMHs; High confidence in function and specificity.
  
 0.921
hupD
Hydrogenase expression/formation protein hupD, 54% identity,(63% simialrity) to SwissProt:Q03004. Aliases: hoxM(SwissProt:P40591), hyaD(E.coli). Has PF01750:Hydrogenase maturation protease;The family consists of hydrogenase maturation proteases. In E. coli HypI the hydrogenase maturation protease is involved in processing of HypE the large subunit of hydrogenases 3, by cleavage of its C-terminal. IPR000671:Peptidase_M52; TIGR00072; hydrog_prot; Signal P reporting SIgnal peptide Present. No TMH present; High confidence in function and specificity.
 
 
 0.909
hoxC
Probable ferredoxin hydrogenase, large subunit. Homology to hoxC of A. hydrogenophilus of 59% (trembl|P94155). InterPro: Nickel-dependent hydrogenases large subunit.
  
  
 
0.903
hupH
Hydrogenase expression/formation protein hupH, 58% similarity to SwissProt:Q03007. TrEMBL;Q6PTB0,TrEMBL;P95499, SwissProt;P19932. Has PF04809(IPR006894):HupH hydrogenase expression protein, C-terminal conserved region;This family represents a C-terminal conserved region found in these bacterial proteins necessary for hydrogenase synthesis. Their precise function is unknown. No Signal peptide or TMH reported Present; High confidence in function and specificity.
 
  
 0.882
hupK
Putative hydrogenase expression/formation protein HupK. Homology to hupK of R. leguminosarum of 33% (gi|48731|emb|CAA37158.1|(NCBI ENTREZ). No domains predicted. No signal peptide or TMH present., ; Family membership.
 
  
  0.858
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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