STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
hypAProbable hydrogenase nickel inorporation protein hypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (114 aa)    
Predicted Functional Partners:
hupK
Putative hydrogenase expression/formation protein HupK. Homology to hupK of R. leguminosarum of 33% (gi|48731|emb|CAA37158.1|(NCBI ENTREZ). No domains predicted. No signal peptide or TMH present., ; Family membership.
 
 
 0.981
hypB
Probable hydrogenase accessory protein HypB. Homology to hypB of E. coli of 56% (sprot|HYPB_ECOLI). IS REQUIRED FOR THE FORMATION OF HYDROGENASE ISOENZYMES. AFFECTS SOME ASPECT OF THE PROCESSING OF HYDROGENASES and NICKEL INCORPORATION scince HYPB GENE LESIONS CAN BE COMPLEMENTED BY HIGH NICKEL ION CONCENTRATION IN THE MEDIUM. Pfam: HypB/UreG nucleotide-binding domain Tigrfam: hypB: hydrogenase accessory protein Hyp no signal peptide no TMHs; High confidence in function and specificity.
 
 
 0.978
hoxC
Probable ferredoxin hydrogenase, large subunit. Homology to hoxC of A. hydrogenophilus of 59% (trembl|P94155). InterPro: Nickel-dependent hydrogenases large subunit.
 
 
 0.957
hupL
Probable ferredoxin hydrogenase, large subunit. Homology to hoxG of A. eutrophus of 68% (>sprot|MBHL_ALCEU). This enzyme recycles the H(2) produced by nitrogenase to increase the production of ATP and to protect nitrogenase against inhibition or damage by O(2) under carbon- or phosphate-limited conditions. Pfam: Nickel dpendent hydrogenase no signal peptide no TMHs; High confidence in function and specificity.
 
 
 0.951
hypD
Hydrogenase expression/formation protein hypD. Homology to hypD of A. eutrophus of 71% (sprot|HYPD_ALCEU). HypD is involved in hydrogenase formation. InterPro: Hydrogenase formation hypA (IPR002780) Pfam: Hydrogenase formation hypA family Tigrfam: hypD: hydrogenase expression/formation no signal peptide no TMHs; High confidence in function and specificity; Belongs to the HypD family.
 
  
 0.935
hypC
Probable hydrogenase assembly chaperon HypC. Homology to hypC of R. leguminosarum of 61% (sprot|HYPC_RHILV). Forms a family of small proteins that are hydrogenase precursor-specific chaperones required for this maturation process. They are believed to keep the hydrogenase precursor in a conformation accessible for metal incorporation. Pfam: HypF/HypC family Tigrfam: hypC_hupF: hydrogenase assembly chaperone no signal peptide no TMHs; Function unclear.
 
  
 0.931
hypF
Probable hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
   
 0.923
hypE
Hydrogenase expression/formation protein hypE, 64% Identity to SProt;P31905,TrEMBL;Q6NB52(60% Identity),Q83WU6. Has PF00586, AIR synthase related protein, N-terminal domain;IPR000728 AIR_synth; This family includes Hydrogen expression/formation protein, HypE, which may be involved inthe maturation of NifE hydrogenase; AIR synthase and FGAM synthase, which are involved in de novo purine biosynthesis; and selenide, water dikinase, an enzyme which synthesizes selenophosphate from selenide and ATP. PF02769, AIR synthase related protein, C-terminal domain;IPR010918 AIR_synth_C; This entry i [...]
 
  
 0.913
hupJ
Probable Hydrogenase expression/formation protein hupJ, 52% similarity to SwissProtP28152. Alias:hybE No Signal Peptide or TMH reported present. thiM: hydroxyethylthiazole kinase.
 
  
 0.900
hupD
Hydrogenase expression/formation protein hupD, 54% identity,(63% simialrity) to SwissProt:Q03004. Aliases: hoxM(SwissProt:P40591), hyaD(E.coli). Has PF01750:Hydrogenase maturation protease;The family consists of hydrogenase maturation proteases. In E. coli HypI the hydrogenase maturation protease is involved in processing of HypE the large subunit of hydrogenases 3, by cleavage of its C-terminal. IPR000671:Peptidase_M52; TIGR00072; hydrog_prot; Signal P reporting SIgnal peptide Present. No TMH present; High confidence in function and specificity.
 
  
 0.885
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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