STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hypEHydrogenase expression/formation protein hypE, 64% Identity to SProt;P31905,TrEMBL;Q6NB52(60% Identity),Q83WU6. Has PF00586, AIR synthase related protein, N-terminal domain;IPR000728 AIR_synth; This family includes Hydrogen expression/formation protein, HypE, which may be involved inthe maturation of NifE hydrogenase; AIR synthase and FGAM synthase, which are involved in de novo purine biosynthesis; and selenide, water dikinase, an enzyme which synthesizes selenophosphate from selenide and ATP. PF02769, AIR synthase related protein, C-terminal domain;IPR010918 AIR_synth_C; This entry i [...] (350 aa)    
Predicted Functional Partners:
hypD
Hydrogenase expression/formation protein hypD. Homology to hypD of A. eutrophus of 71% (sprot|HYPD_ALCEU). HypD is involved in hydrogenase formation. InterPro: Hydrogenase formation hypA (IPR002780) Pfam: Hydrogenase formation hypA family Tigrfam: hypD: hydrogenase expression/formation no signal peptide no TMHs; High confidence in function and specificity; Belongs to the HypD family.
 
 
 0.997
hypF
Probable hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
 
 0.992
hypC
Probable hydrogenase assembly chaperon HypC. Homology to hypC of R. leguminosarum of 61% (sprot|HYPC_RHILV). Forms a family of small proteins that are hydrogenase precursor-specific chaperones required for this maturation process. They are believed to keep the hydrogenase precursor in a conformation accessible for metal incorporation. Pfam: HypF/HypC family Tigrfam: hypC_hupF: hydrogenase assembly chaperone no signal peptide no TMHs; Function unclear.
 
 
 0.988
hypB
Probable hydrogenase accessory protein HypB. Homology to hypB of E. coli of 56% (sprot|HYPB_ECOLI). IS REQUIRED FOR THE FORMATION OF HYDROGENASE ISOENZYMES. AFFECTS SOME ASPECT OF THE PROCESSING OF HYDROGENASES and NICKEL INCORPORATION scince HYPB GENE LESIONS CAN BE COMPLEMENTED BY HIGH NICKEL ION CONCENTRATION IN THE MEDIUM. Pfam: HypB/UreG nucleotide-binding domain Tigrfam: hypB: hydrogenase accessory protein Hyp no signal peptide no TMHs; High confidence in function and specificity.
 
  
 0.932
hypA
Probable hydrogenase nickel inorporation protein hypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
  
 0.915
hupF
Putative Hydrogenase expression/formation protein hupF,43% similarity to TrEMBL; Q6PTB2. No Signal Peptide or TMH reported present. Has PF01455:HupF/HypC family(IPR001109);The large subunit of [NiFe]-hydrogenase,as well as other nickel metalloenzymes, is synthesized as a precursor devoid of the metalloenzyme active site. This precursor then undergoes a complex post-translational maturation process that requires a number of accessory proteins. The hydrogenase expression/formation proteins (HUPF/HYPC) form a family of small proteins that are hydrogenase precursor-specific chaperones requ [...]
  
 
 0.893
hoxH
Probable hydrogen dehydrogenase, beta subunit. Homology to hoxH of a. eutrophus of 48% (sprot|HOXH_ALCEU). Pfam: Nickel-dependent hydrogenase no signal peptide no TMHs; High confidence in function and specificity; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
   
 0.785
hoxC
Probable ferredoxin hydrogenase, large subunit. Homology to hoxC of A. hydrogenophilus of 59% (trembl|P94155). InterPro: Nickel-dependent hydrogenases large subunit.
 
   
 0.759
hoxA
Hydrogenase transcriptional regulatory protein,; High confidence in function and specificity.
  
    0.744
hoxY
Probable hydrogen dehydrogenase, delta subunit. Homology to hoxY of a. eutrophus of 45% (sprot|HOXY_ALCEU). InterPro: Respiratory-chain NADH dehydrogenase 20 Kd subunit Pfam: NADH ubiquinone oxidoreductase, 20 kD subunit no signal peptie no TMHs; High confidence in function and specificity.
 
   
 0.660
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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