STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hoxBFerredoxin hydrogenase, small subunit. Homology to hoxB of A. hydrogenophilus of 75% (TREMBL:P94154). Hydrogenases catalyse the reversible oxidation of molecular hydrogen and play a vital role in anaerobic metabolism. InterPro: Hydrogenase (NiFe) small subunit HydA (IPR001821); Respiroatory-chain NADH dehydrogenase 20 kD subunit (IPR006137) Tigrfam: hydA: hydrogenase (NiFe) small subunit (hydA) Pfam: NADH ubiquinone oxidoreductase no signal peptide no TMHs; High confidence in function and specificity. (331 aa)    
Predicted Functional Partners:
hoxC
Probable ferredoxin hydrogenase, large subunit. Homology to hoxC of A. hydrogenophilus of 59% (trembl|P94155). InterPro: Nickel-dependent hydrogenases large subunit.
 
 0.999
hupL
Probable ferredoxin hydrogenase, large subunit. Homology to hoxG of A. eutrophus of 68% (>sprot|MBHL_ALCEU). This enzyme recycles the H(2) produced by nitrogenase to increase the production of ATP and to protect nitrogenase against inhibition or damage by O(2) under carbon- or phosphate-limited conditions. Pfam: Nickel dpendent hydrogenase no signal peptide no TMHs; High confidence in function and specificity.
 
 0.998
hupC
Probable Ni/Fe-hydrogenase, B-type cytochrome subunit. Homology to hupZ of A. chroococcum of 65% (sprot|CYBH_AZOCH) Probable b-type cytochrome. InterPro: Nickel-dependent hydrogenase b-type cytochrome subunit (IPR000516) Pfam: Nickel-dependent hydrogenase b-type cytrochrome subunit no signal peptide 4 TMHs; High confidence in function and specificity.
 
 
 0.992
hupK
Putative hydrogenase expression/formation protein HupK. Homology to hupK of R. leguminosarum of 33% (gi|48731|emb|CAA37158.1|(NCBI ENTREZ). No domains predicted. No signal peptide or TMH present., ; Family membership.
 
 0.989
hoxJ
Putative hydrogen uptake histidine-kinase,ATPbind_ATPase. IPR004358; Bact_sens_pr_C. IPR005467; His_kinase. IPR003661; His_kinA_N. IPR009082; His_kin_homodim. IPR001610; PAC. IPR000700; PAS-assoc_C. IPR000014; PAS_domain. Pfam: PF02518; HATPase_c. PF00512; HisKA. SMART: SM00387; HATPase_c. SM00388; HisKA. SM00086; PAC. SM00091; PAS; High confidence in function and specificity.
 
 
 0.981
hupS
Ferredoxin hydrogenase, small subunit. Homology to hoxK of A. eutrophus of 83% (sprot:MBHS_ALCEU). This enzyme recycles the H(2) produced by nitrogenase to increase the production of ATP and to protect nitrogenase against inhibition or damage by O(2) under carbon- or phosphate-limited conditions. Tigrfam: hydA: hydrogenase (NiFe) small subunit Pfam: NADH ubiquinone oxidoreductase 20kD signal peptide no TMHs; High confidence in function and specificity.
  
  
 
0.938
hupH
Hydrogenase expression/formation protein hupH, 58% similarity to SwissProt:Q03007. TrEMBL;Q6PTB0,TrEMBL;P95499, SwissProt;P19932. Has PF04809(IPR006894):HupH hydrogenase expression protein, C-terminal conserved region;This family represents a C-terminal conserved region found in these bacterial proteins necessary for hydrogenase synthesis. Their precise function is unknown. No Signal peptide or TMH reported Present; High confidence in function and specificity.
 
 
 0.934
hupJ
Probable Hydrogenase expression/formation protein hupJ, 52% similarity to SwissProtP28152. Alias:hybE No Signal Peptide or TMH reported present. thiM: hydroxyethylthiazole kinase.
 
 
 0.897
hupI
Probable rubredoxin protein, 61% Identity to SProt;P30778, P31912. Has PF00301, Rubredoxin;Rubredoxin is a low molecular weight iron-containing bacterial protein involved in electron transfer,sometimes replacing ferredoxin as an electron carrier. No signal peptide. No TMHs; High confidence in function and specificity; Belongs to the rubredoxin family.
 
 
 0.882
hupD
Hydrogenase expression/formation protein hupD, 54% identity,(63% simialrity) to SwissProt:Q03004. Aliases: hoxM(SwissProt:P40591), hyaD(E.coli). Has PF01750:Hydrogenase maturation protease;The family consists of hydrogenase maturation proteases. In E. coli HypI the hydrogenase maturation protease is involved in processing of HypE the large subunit of hydrogenases 3, by cleavage of its C-terminal. IPR000671:Peptidase_M52; TIGR00072; hydrog_prot; Signal P reporting SIgnal peptide Present. No TMH present; High confidence in function and specificity.
 
  
 0.873
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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