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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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[Homology]
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mscLLarge-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. (141 aa)    
Predicted Functional Partners:
ribH
Riboflavin synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
  
  
 0.906
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
   
    0.831
azo3820
ABC transporter permease protein; Branched-chain amino acid transport system typically composed of a periplasmic substrate-binding protein, one or two reciprocally homologous integral inner-membrane proteins and one or two peripheral membrane ATP-binding proteins that couple energy to the active transport system.The integral inner-membrane proteins translocate the substrate across the membrane. Similar to trembl|Q89C65 (46%), to sprot|LIVH_ECOLI (33%) and to sprot|BRAD_PSEAE (30%). Pfam (PF02653): Binding-system dependent bacterial transporters (araH, livH/limM families) TMHMM reportin [...]
       0.515
ncd2-2
2-nitropropane dioxygenase precursor (EC 1.13.11.32) (Nitroalkane oxidase) (2-NPD). SPROT:Q01284: 28% identity, 44% similarity CATALYZES THE OXIDATION OF NITROALKANES TO PRODUCE THE CORRESPONDING CARBONYL COMPOUNDS. IT ACTS ON 2-NITROPROPANE BETTER THAN ON NITROETHANE AND 1-NITROPROPANE AND ANIONIC FORMS OF NITROALKANES ARE MUCH BETTER SUBSTRATES THAN ARE NEUTRAL FORMS. InterPro: 2-nitropropane dioxygenase InterPro; IPR004136; 2nprop_dioxygen. InterPro; IPR003009; FMN_enzyme. Pfam; PF03060; NPD thiE: thiamine-phosphate pyrophosphoryl Non-secretory protein with signal peptide probabilit [...]
       0.515
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.513
azo2412
Sensor histidine kinase mtrB (EC 2.7.3.-). Member of the two-component regulatory system mtrA/mtrB. Seems to function as a membrane-associated protein kinase that phosphorylates mtrA in response to environmental signals (By similarity). TREMBLnew:AAS80811; TREMBL:Q8PEZ5, 42% identity, 59% similarity; Pfam: Histidine kinase _,Phosphoacceptor domain. TIGRFAM: sss: sodium solute transporter sup. TMHMM predicted transmembrane helices. sss: SSS sodium solute transporter sup; Specificity unclear.
     
 0.500
recA
Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
     
 0.436
icmF
Probable methylmalonyl-coa mutase protein; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
      
 0.436
rosB
Putative Potassium/proton antiporter; Probable potassium antiporter, rosB. 38% HPr_SerP_S.IPR004771; K_eff.IPR006153; Na_H_porter. IPR003148; TrkA_N. Pfam:PF00999; Na_H_Exchanger; 1.PF02254; TrkA_N; 1. TIGRFAMs:TIGR00932; 2a37; 1. TMhelix: 12; High confidence in function and specificity; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.
      
 0.421
azo1130
S-adenosylmethionine:2-demethylmenaquinone methyltransferase; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
   
  
 0.416
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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