STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fabF23-oxoacyl-[acyl-carrier-protein] synthase; CATALYZES THE CONDENSATION REACTION OF FATTY ACID SYNTHESIS BY THE ADDITION TO AN ACYL ACCEPTOR OF TWO CARBONS FROM MALONYL-ACP. HAS A PREFERENCE FOR SHORT CHAIN ACID SUBSTRATES AND MAY FUNCTION TO SUPPLY THE OCTANOIC SUBSTRATES FOR LIPOIC ACID BIOSYNTHESIS (BY SIMILARITY),TREMBL:Q8P3S1 (45% identity); TREMBL:Q87CD9 (41% identity). InterPro (IPR000794): Beta-ketoacyl synthase. Pfam (PF02801): Beta-ketoacyl synthase, C-terminal domain. Pfam (PF00109): Beta-ketoacyl synthase, N-terminal domain. Signal P reporting signal peptide; High confidence [...] (401 aa)    
Predicted Functional Partners:
fabG2
3-oxoacyl-[acyl-carrier protein] reductase; The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases,TREMBL:Q8PF93 (52% identity); TREMBL:Q8Y2A1 (53% identity). Pfam (PF00106): Short chain dehydrogenase; High confidence in function and specificity.
 
 0.997
fabD
Probable malonyl CoA-acyl carrier protein transacylase. Homology to fabD of E. coli of 54% (sprot|FABD_ECOLI). Is involved in fatty acid biosynthesis and transfers the malonyl moeity from coenzyme A to acyl-carrier protein. InterPro: Acyl transferase domain (IPR001227); Manyl CoA-acyl carrier protein transaylase (IPR004410) Pfam: Acyl transferase domain Tigrfam: fabD: malonyl CoA-acyl carrier protein no signal peptide no TMHs; High confidence in function and specificity.
 0.988
fabH
Probable 3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
 
 
 0.986
fabI1
Probable enoyl-acyl carrier protein reductase; CATALYTIC ACTIVITY: Acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH Entry name:- SWISSPROT:FABI_PSEAE Prim. accession # Q9ZFE4 Identities = 173/260 (66%) InterPro :- IPR002198; ADH_short. Pfam:- PF00106; adh_short; 1. Prediction: Non-secretory protein Signal peptide probability: 0.044 Number of predicted TMHs: 0; High confidence in function and specificity.
 
 
 0.978
fabI2
Probable enoyl-[acyl-carrier-protein] reductase; Catalytic activity :-acyl-[acyl-carrier protein] + nad(+) = trans- 2,3-dehydroacyl-[acyl-carrier protein] + nadh. pathway:- fatty acid biosynthesis pathway; second reduction step. Entry name SWISSPROT:FABI_ECOLI InterPro IPR002198; ADH_short. Identities = 108/252 (42%) Pfam PF00106; adh_short; 1. Prediction: Non-secretory protein Signal peptide probability: 0.00 Number of predicted TMHs: 0; High confidence in function and specificity.
 
 
 0.970
fabG1
3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
 0.969
azo3912
Conserved hypothetical protein. Homology to RSc0426 of R.solanacearum of 51% (trembl:Q8Y2B0). No domains predicted. No signal peptide. No TMHs.
     0.965
azo0260
Conserved hypothetical protein; Entry name:- TREMBL:Q87EI7 InterPro:- IPR000873; AMP-bind. Pfam:- PF00501; AMP-binding; 2. Identity :- 45% Prediction: Non-secretory protein Signal peptide probability: 0.000 Number of predicted TMHs: 0.
 
 0.962
azo3913
Conserved hypothetical protein; Entry name:- TREMBL:Q8Y2B1 Prim. accession # Q8Y2B1 Identities = 64/116 (55%) Prediction: Non-secretory protein Signal peptide probability: 0.000 Number of predicted TMHs: 0.
 
  
 0.962
azo0259
Conserved hypothetical protein. Homology to xac 4098 of X. axonapodis of 36% (trembl|Q8PF87). No domains predicted. No signal peptide. No TMHs.
 
 0.959
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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