STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo3955Conserved hypothetical protein. Homology to Daro03000439 of Dechloromonas aromatica of 48% (gi|41725494|ref|ZP_00152252.1|(NBCI ENTREZ)). No domains predicted. No signal peptide. No TMHs. (255 aa)    
Predicted Functional Partners:
azo3956
Conserved hypothetical protein, has weak homlogs in the Database. TrEMBL;Q88I83(25% Identity). gi|46140644|ref|ZP_00152253.2|, 30% Identity to Dechloromonas aromatica RCB,Nucleotidyltransferase/DNA polymerase involved in DNA repair Has PF00817,impB/mucB/samB family; IPR001126, UMUC_like; These proteins are involved in UV protection.In Escherichia coli, UV and many chemicals appear to cause mutagenesis by a process of translesion synthesis that requires DNA polymerase III and the SOS-regulated proteins UmuD, UmuC and RecA. This machinery allows the replication to continue through DNA le [...]
 
  
 0.990
dnaE2
DNA polymerase III, alpha subunit, putative; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.
 
  
 0.949
dinP
DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
  
  
 0.864
lexA
Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
 
   
 0.600
azo3813
Conserved hypothetical ATP-dependent protease La. Homology to rsc0402 of R. solanacearum of 44% (trembl|Q8Y2D4). N-terminal domain of the ATP-dependent protease La (LON), present also in other bacterial ORFs. InterPro: ATP-dependent protease La (LON) domain (IPR003111). Pfam: ATP-dependent protease La (LON) domain. no signal peptide. no TMHs; Conserved hypothetical protein.
  
     0.566
recA
Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
     
 0.555
azo3298
Conserved hypothetical membrane protein. Homology to rs0336 of R. solanacearum of 53% (trembl|Q8Y2G8(SRS)). no domains predicted. signal peptide. 1 TMH; Conserved hypothetical protein.
  
     0.552
dnaE1
DNA-directed DNA polymerase; DNA polymerase III alpha subunit. DNA POLYMERASE III IS A COMPLEX MULTICHAIN ENZYME RESPONSIBLE FOR MOST OF THE REPLICATIVE SYNTHESIS IN BACTERIA. THIS DNA POLYMERASE ALSO EXHIBITS 3 TO 5 EXONUCLEASE ACTIVITY. THE ALPHA CHAIN IS THE DNA POLYMERASE (BY SIMILARITY). InterPro: DNA polymerase III alpha subunit TIGRFAM: polc: DNA polymerase III alpha subunit; High confidence in function and specificity.
  
  
 0.470
azo0822
Probable Hypothetical UPF0028 family protein YML059C. TREMBL:Q82SM1: 50% identity, 68% similariry InterPro:IPR002641; Patatin. Pfam:PF01734; Patatin bioF: 8-amino-7-oxononanoate synthase Signal peptide present (SinalP predicted) TMHMM predicted TMH's; Function unclear.
  
     0.439
recN
DNA repair protein; May be involved in recombinational repair of damaged DNA.
   
  
 0.433
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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