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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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[Homology]
Score
metXProbable homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (375 aa)    
Predicted Functional Partners:
metW
Putative methionine biosynthesis protein; Q8YDE4:20% identity, 37% similarity. Ubiquinone/menaquinone biosynthesis methyltransferase ubiE. Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-14-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-14-benzoquinol (DMQH2) (By similarity). METHIONINE BIOSYNTHESIS PROTEIN Pfam:PPTA(protein prenyl transferase alpha subunit), FERM domain TIGRFAM:rmJ: ribosomal RNA large subunit methylation InterPro IPR000051; SAM_bind. IPR004034; Ubi/men_Metransf. I [...]
 
 0.998
azo2193
Probable O-acetylhomoserine aminocarboxypropyltransferase. Homology to cysD of A. nidulans of 51% (sprot|CYSD_EMENI). Transforms O-acetylhomoserine into homocysteine. Pfam: Cys/Met metabolism PLP-dependent enzyme no signal peptide no TMHs; High confidence in function and specificity.
 
 
 0.977
azo1422
Probable O-acetylhomoserine aminocarboxypropyltransferase. Homology with cysD of A. nidulans of 54% (sprot|CYSD_EMENI). Transforms O-acetylhomoserine into homocysteine. InterPro: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes (IPR000277) Pfam: Cys/Met metabolism PLP-dependent enzyme no signal peptide no TMHs; High confidence in function and specificity.
 
 
 0.976
metH
Probable methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.975
metZ
Cys/Met metabolism pyridoxal-phosphate-dependent enzyme; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.
 
  
 0.940
azo0472
Probable O-acetylhomoserine aminocarboxypropyltransferase. Homology to cysD of A. nidulans of 54% (sprot|CYSD_EMENI). Transforms O-acetylhomoserine into homocysteine. InterPro: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes (IPR000277) Pfam: Cys/Met metabolism PLP-dependent enzymes no signal peptide no TMHs; High confidence in function and specificity.
 
 
 0.933
hom
Homoserine dehydrogenase catalyzes NAD-dependent reduction of aspartate beta-semialdehyde into homoserine. This reaction is the third step in a pathway leading from aspartate to homoserine. Similar to TREMBL:Q9RAM9 (77%) and to pir|DEPSHA(PIR (Georgetown University) (56%). Pfam: Homoserine dehydrogenase; High confidence in function and specificity.
 
 0.931
ilvA
Probable threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.888
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.875
thrH
Probable homoserine kinase; ThrH encodes a protein with an in vivo homoserine-kinase-like activity in P. aeruginosa. Homoserine kinase,the product of the thrB gene, catalyzes an obligatory step of threonine biosynthesis. Similar trembl|Q9I2Y2 (62%). Pfam (PF00702): haloacid dehalogenase-like hydrolase; Function unclear.
   
 
 0.859
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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