STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
iscSCysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (405 aa)    
Predicted Functional Partners:
iscU
FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
 
 0.999
cyaY
Iron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.
   
 0.993
EEP68218.1
ThiF family protein; KEGG: rme:Rmet_0249 2.9e-63 UBA/ThiF-type NAD/FAD binding fold.
   
 0.991
EEP66970.1
Hypothetical protein; Belongs to the sulfur carrier protein TusA family.
   
 0.991
EEP67991.1
Putative iron-sulfur cluster assembly transcription factor IscR; KEGG: ama:AM656 2.4e-15 aminotransferase, class V K04487.
 
  
 0.967
iscA
Iron-sulfur cluster assembly protein IscA; KEGG: lin:lin1472 0.0031 similar to glutathione reductase K00383; Psort location: Cytoplasmic, score: 8.96; Belongs to the HesB/IscA family.
 
  
 0.922
fdx
Ferredoxin, 2Fe-2S type, ISC system; KEGG: eci:UTI89_C2847 5.5e-44 fdx; ferredoxin, 2Fe-2S K04755; Psort location: Cytoplasmic, score: 8.96.
 
 0.921
hscB
Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.
 
 
 0.912
EEP68967.1
Oxidoreductase NAD-binding domain protein; KEGG: tbd:Tbd_2563 2.1e-74 NAD(P)H-flavin reductase K00523.
  
 0.864
EEP67661.1
2Fe-2S iron-sulfur cluster binding domain protein; KEGG: bpe:BP0362 1.1e-08 CDP-6-deoxy-delta-3,4-glucoseen reductase K00523; Psort location: Cytoplasmic, score: 8.96.
  
 0.755
Your Current Organism:
Kingella oralis
NCBI taxonomy Id: 629741
Other names: K. oralis ATCC 51147, Kingella oralis ATCC 51147, Kingella oralis str. ATCC 51147, Kingella oralis strain ATCC 51147
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