STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDS03094.1Dihydrofolate reductase. (192 aa)    
Predicted Functional Partners:
SDT14658.1
Dihydrofolate reductase.
  
     0.775
SDT39568.1
Dihydrofolate reductase.
  
     0.668
SDT45635.1
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
     
 0.650
SDT36731.1
Dihydrofolate reductase.
  
     0.617
SDS74219.1
Dihydrofolate reductase.
  
     0.549
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
   
 
  0.529
SDS79356.1
Dihydrofolate reductase.
  
     0.507
SDS68031.1
Dihydrofolate reductase.
  
     0.446
SDT20605.1
Dihydrofolate reductase.
  
     0.423
Your Current Organism:
Microlunatus soli
NCBI taxonomy Id: 630515
Other names: CCM 7685, DSM 21800, M. soli, Microlunatus soli Kampfer et al. 2010, Microlunatus sp. CC-012602, strain CC-012602, strain CC-12602
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