node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDS61213.1 | SDS61248.1 | SAMN04489812_2446 | SAMN04489812_2447 | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | Aminomethyltransferase; Belongs to the GcvT family. | 0.951 |
SDS61213.1 | SDS61345.1 | SAMN04489812_2446 | SAMN04489812_2450 | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family. | 0.931 |
SDS61213.1 | SDT40747.1 | SAMN04489812_2446 | SAMN04489812_5655 | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | Glutamate synthase (NADH) large subunit. | 0.538 |
SDS61213.1 | SDT45635.1 | SAMN04489812_2446 | SAMN04489812_5958 | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.993 |
SDS61213.1 | fhs | SAMN04489812_2446 | SAMN04489812_2445 | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.915 |
SDS61213.1 | gcvP | SAMN04489812_2446 | SAMN04489812_6058 | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.519 |
SDS61213.1 | glyA | SAMN04489812_2446 | SAMN04489812_1815 | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.833 |
SDS61248.1 | SDS61213.1 | SAMN04489812_2447 | SAMN04489812_2446 | Aminomethyltransferase; Belongs to the GcvT family. | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | 0.951 |
SDS61248.1 | SDS61345.1 | SAMN04489812_2447 | SAMN04489812_2450 | Aminomethyltransferase; Belongs to the GcvT family. | Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family. | 0.912 |
SDS61248.1 | SDT36548.1 | SAMN04489812_2447 | SAMN04489812_5415 | Aminomethyltransferase; Belongs to the GcvT family. | 2-oxoglutarate dehydrogenase E1 component. | 0.902 |
SDS61248.1 | SDT40747.1 | SAMN04489812_2447 | SAMN04489812_5655 | Aminomethyltransferase; Belongs to the GcvT family. | Glutamate synthase (NADH) large subunit. | 0.898 |
SDS61248.1 | SDT41310.1 | SAMN04489812_2447 | SAMN04489812_5687 | Aminomethyltransferase; Belongs to the GcvT family. | Glycine/D-amino acid oxidase. | 0.874 |
SDS61248.1 | SDT45635.1 | SAMN04489812_2447 | SAMN04489812_5958 | Aminomethyltransferase; Belongs to the GcvT family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.861 |
SDS61248.1 | fhs | SAMN04489812_2447 | SAMN04489812_2445 | Aminomethyltransferase; Belongs to the GcvT family. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.958 |
SDS61248.1 | gcvH | SAMN04489812_2447 | SAMN04489812_6066 | Aminomethyltransferase; Belongs to the GcvT family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.998 |
SDS61248.1 | gcvP | SAMN04489812_2447 | SAMN04489812_6058 | Aminomethyltransferase; Belongs to the GcvT family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
SDS61248.1 | glyA | SAMN04489812_2447 | SAMN04489812_1815 | Aminomethyltransferase; Belongs to the GcvT family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.930 |
SDS61345.1 | SDS61213.1 | SAMN04489812_2450 | SAMN04489812_2446 | Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family. | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | 0.931 |
SDS61345.1 | SDS61248.1 | SAMN04489812_2450 | SAMN04489812_2447 | Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family. | Aminomethyltransferase; Belongs to the GcvT family. | 0.912 |
SDS61345.1 | SDT36548.1 | SAMN04489812_2450 | SAMN04489812_5415 | Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family. | 2-oxoglutarate dehydrogenase E1 component. | 0.970 |