STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
COQ6Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (506 aa)    
Predicted Functional Partners:
COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2).
   
 0.964
COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
 
 
 0.938
A0A2P5FI79
Magnesium-protoporphyrin IX methyltransferase.
   
 0.885
A0A2P5API6
4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
  
  
 0.846
A0A2P5BZS3
Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
   
 
 0.801
A0A2P5FB28
SAM-binding methyltransferase MPBQ/MBSQ; Belongs to the class I-like SAM-binding methyltransferase superfamily. MPBQ/MBSQ MT family.
   
 0.798
A0A2P5FWB7
SAM-binding methyltransferase MPBQ/MBSQ; Belongs to the class I-like SAM-binding methyltransferase superfamily. MPBQ/MBSQ MT family.
   
 0.798
A0A2P5EPL1
PQQ-dependent membrane bound dehydrogenase, glucose/quinate/shikimate-related.
   
 
 0.775
MENG
2-phytyl-1,4-beta-naphthoquinone methyltransferase, chloroplastic; Involved in the biosynthesis of phylloquinone (vitamin K1). Methyltransferase required for the conversion of 2-phytyl-1,4-beta- naphthoquinol to phylloquinol.
   
 0.771
A0A2P5D3A0
Phenol hydroxylase reductase.
   
 0.721
Your Current Organism:
Trema orientale
NCBI taxonomy Id: 63057
Other names: Celtis orientalis, Sponia africana, T. orientale, Trema africana, Trema africanum, Trema orientalis
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