node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A0A2P5AH35 | A0A2P5EJ96 | A0A2P5AH35 | A0A2P5EJ96 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Belongs to the ATG12 family. | Autophagy-related protein 3. | 0.999 |
A0A2P5AH35 | MOCS3 | A0A2P5AH35 | A0A2P5F287 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Belongs to the ATG12 family. | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] | 0.858 |
A0A2P5CB35 | A0A2P5F2Z9 | A0A2P5CB35 | A0A2P5F2Z9 | Sulfurtransferase. | Cysteine desulfurase IscS. | 0.928 |
A0A2P5CB35 | A0A2P5F6T0 | A0A2P5CB35 | A0A2P5F6T0 | Sulfurtransferase. | Uncharacterized protein. | 0.791 |
A0A2P5CB35 | A0A2P5FUQ2 | A0A2P5CB35 | A0A2P5FUQ2 | Sulfurtransferase. | Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. | 0.791 |
A0A2P5CB35 | MOCS3 | A0A2P5CB35 | A0A2P5F287 | Sulfurtransferase. | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] | 0.939 |
A0A2P5E6J5 | A0A2P5F6T0 | A0A2P5E6J5 | A0A2P5F6T0 | Molybdenum cofactor biosynthesis protein A. | Uncharacterized protein. | 0.891 |
A0A2P5E6J5 | A0A2P5FHQ7 | A0A2P5E6J5 | A0A2P5FHQ7 | Molybdenum cofactor biosynthesis protein A. | Molybdenum cofactor biosynthesis C. | 0.988 |
A0A2P5E6J5 | A0A2P5FUQ2 | A0A2P5E6J5 | A0A2P5FUQ2 | Molybdenum cofactor biosynthesis protein A. | Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. | 0.965 |
A0A2P5E6J5 | MOCS3 | A0A2P5E6J5 | A0A2P5F287 | Molybdenum cofactor biosynthesis protein A. | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] | 0.859 |
A0A2P5EI29 | MOCS3 | A0A2P5EI29 | A0A2P5F287 | Ubiquitin-related modifier 1 homolog; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress spec [...] | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] | 0.984 |
A0A2P5EJ96 | A0A2P5AH35 | A0A2P5EJ96 | A0A2P5AH35 | Autophagy-related protein 3. | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Belongs to the ATG12 family. | 0.999 |
A0A2P5EJ96 | MOCS3 | A0A2P5EJ96 | A0A2P5F287 | Autophagy-related protein 3. | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] | 0.908 |
A0A2P5F2Z9 | A0A2P5CB35 | A0A2P5F2Z9 | A0A2P5CB35 | Cysteine desulfurase IscS. | Sulfurtransferase. | 0.928 |
A0A2P5F2Z9 | A0A2P5FUQ2 | A0A2P5F2Z9 | A0A2P5FUQ2 | Cysteine desulfurase IscS. | Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. | 0.427 |
A0A2P5F2Z9 | A0A2P5FX78 | A0A2P5F2Z9 | A0A2P5FX78 | Cysteine desulfurase IscS. | Rhodanese-like domain containing protein. | 0.928 |
A0A2P5F2Z9 | MOCS3 | A0A2P5F2Z9 | A0A2P5F287 | Cysteine desulfurase IscS. | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] | 0.970 |
A0A2P5F6T0 | A0A2P5CB35 | A0A2P5F6T0 | A0A2P5CB35 | Uncharacterized protein. | Sulfurtransferase. | 0.791 |
A0A2P5F6T0 | A0A2P5E6J5 | A0A2P5F6T0 | A0A2P5E6J5 | Uncharacterized protein. | Molybdenum cofactor biosynthesis protein A. | 0.891 |
A0A2P5F6T0 | A0A2P5FHQ7 | A0A2P5F6T0 | A0A2P5FHQ7 | Uncharacterized protein. | Molybdenum cofactor biosynthesis C. | 0.891 |