node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cvpA | dedD | EBL_c12340 | EBL_c12330 | Membrane protein required for colicin V production; (Alpha,alpha-trehalase)(Alpha,alpha-trehalose glucohydrolase). | DedD protein; Non-essential cell division protein that could be required for efficient cell constriction. | 0.683 |
cvpA | folC | EBL_c12340 | EBL_c12320 | Membrane protein required for colicin V production; (Alpha,alpha-trehalase)(Alpha,alpha-trehalose glucohydrolase). | Bifunctional folylpolyglutamate synthase/dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.545 |
cvpA | metJ | EBL_c12340 | EBL_c38560 | Membrane protein required for colicin V production; (Alpha,alpha-trehalase)(Alpha,alpha-trehalose glucohydrolase). | Met regulon regulatory protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | 0.543 |
cvpA | purC | EBL_c12340 | EBL_c10740 | Membrane protein required for colicin V production; (Alpha,alpha-trehalase)(Alpha,alpha-trehalose glucohydrolase). | Phosphoribosylaminoimidazole-succinocarboxamide synthetase; Belongs to the SAICAR synthetase family. | 0.795 |
cvpA | purE | EBL_c12340 | EBL_c28140 | Membrane protein required for colicin V production; (Alpha,alpha-trehalase)(Alpha,alpha-trehalose glucohydrolase). | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.704 |
cvpA | purF | EBL_c12340 | EBL_c12350 | Membrane protein required for colicin V production; (Alpha,alpha-trehalase)(Alpha,alpha-trehalose glucohydrolase). | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.956 |
cvpA | purL | EBL_c12340 | EBL_c10080 | Membrane protein required for colicin V production; (Alpha,alpha-trehalase)(Alpha,alpha-trehalose glucohydrolase). | Phosphoribosylformyl-glycineamide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.917 |
cvpA | purM | EBL_c12340 | EBL_c10610 | Membrane protein required for colicin V production; (Alpha,alpha-trehalase)(Alpha,alpha-trehalose glucohydrolase). | Phosphoribosylaminoimidazole synthetase. | 0.783 |
cvpA | purN | EBL_c12340 | EBL_c10600 | Membrane protein required for colicin V production; (Alpha,alpha-trehalase)(Alpha,alpha-trehalose glucohydrolase). | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.552 |
cvpA | ygfE | EBL_c12340 | EBL_c06660 | Membrane protein required for colicin V production; (Alpha,alpha-trehalase)(Alpha,alpha-trehalose glucohydrolase). | Putative cytoplasmic protein; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. | 0.545 |
dedD | cvpA | EBL_c12330 | EBL_c12340 | DedD protein; Non-essential cell division protein that could be required for efficient cell constriction. | Membrane protein required for colicin V production; (Alpha,alpha-trehalase)(Alpha,alpha-trehalose glucohydrolase). | 0.683 |
dedD | folC | EBL_c12330 | EBL_c12320 | DedD protein; Non-essential cell division protein that could be required for efficient cell constriction. | Bifunctional folylpolyglutamate synthase/dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.885 |
dedD | metJ | EBL_c12330 | EBL_c38560 | DedD protein; Non-essential cell division protein that could be required for efficient cell constriction. | Met regulon regulatory protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | 0.474 |
dedD | purF | EBL_c12330 | EBL_c12350 | DedD protein; Non-essential cell division protein that could be required for efficient cell constriction. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.549 |
folC | cvpA | EBL_c12320 | EBL_c12340 | Bifunctional folylpolyglutamate synthase/dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | Membrane protein required for colicin V production; (Alpha,alpha-trehalase)(Alpha,alpha-trehalose glucohydrolase). | 0.545 |
folC | dedD | EBL_c12320 | EBL_c12330 | Bifunctional folylpolyglutamate synthase/dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | DedD protein; Non-essential cell division protein that could be required for efficient cell constriction. | 0.885 |
folC | purF | EBL_c12320 | EBL_c12350 | Bifunctional folylpolyglutamate synthase/dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.665 |
metJ | cvpA | EBL_c38560 | EBL_c12340 | Met regulon regulatory protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | Membrane protein required for colicin V production; (Alpha,alpha-trehalase)(Alpha,alpha-trehalose glucohydrolase). | 0.543 |
metJ | dedD | EBL_c38560 | EBL_c12330 | Met regulon regulatory protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | DedD protein; Non-essential cell division protein that could be required for efficient cell constriction. | 0.474 |
purC | cvpA | EBL_c10740 | EBL_c12340 | Phosphoribosylaminoimidazole-succinocarboxamide synthetase; Belongs to the SAICAR synthetase family. | Membrane protein required for colicin V production; (Alpha,alpha-trehalase)(Alpha,alpha-trehalose glucohydrolase). | 0.795 |