STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (197 aa)    
Predicted Functional Partners:
hisI
Histidine biosynthesis bifunctional protein HisI; In the N-terminal section; belongs to the PRA-CH family.
  
 0.999
hisF
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 0.999
hisA
1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA.
 
 0.999
hisB
Histidine biosynthesis bifunctional protein HisB; In the N-terminal section; belongs to the histidinol- phosphatase family.
 
 
 0.999
hisD
Histidinol dehydrogenase HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.998
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
 
  
 0.994
hisC
Histidinol-phosphate aminotransferase HisC; Permease; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.993
purH
Bifunctional AICAR formyltransferase/IMP cyclohydrolase.
    
 0.851
AFJ47797.1
Putative aminotransferase in cobalamin synthesis.
 
  
 0.849
purB
Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
    
  0.814
Your Current Organism:
Shimwellia blattae
NCBI taxonomy Id: 630626
Other names: Escherichia blattae CIP 104942, Escherichia blattae DSM 4481, Escherichia blattae NBRC 105725, S. blattae DSM 4481 = NBRC 105725, Shimwellia blattae CIP 104942, Shimwellia blattae DSM 4481, Shimwellia blattae DSM 4481 = NBRC 105725, Shimwellia blattae NBRC 105725, Shimwellia blattae NBRC 105725 = DSM 4481
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