| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CH53_1552 | apt | CH53_1552 | CH53_2897 | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.902 |
| CH53_1552 | gmk | CH53_1552 | CH53_1828 | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.900 |
| CH53_1552 | gpt | CH53_1552 | CH53_2800 | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.902 |
| CH53_1552 | guaA | CH53_1552 | CH53_620 | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.916 |
| CH53_1552 | guaB | CH53_1552 | CH53_621 | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.908 |
| CH53_1552 | guaC | CH53_1552 | CH53_1004 | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.908 |
| CH53_1552 | hpt | CH53_1552 | CH53_983 | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | HGPRTase: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.900 |
| CH53_1552 | purA | CH53_1552 | CH53_1333 | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.904 |
| CH53_1552 | purH | CH53_1552 | CH53_2111 | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | purH: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.903 |
| CH53_1552 | surE | CH53_1552 | CH53_927 | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | 5'/3'-nucleotidase SurE; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. | 0.911 |
| apt | CH53_1552 | CH53_2897 | CH53_1552 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | 0.902 |
| apt | gmk | CH53_2897 | CH53_1828 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.953 |
| apt | gpt | CH53_2897 | CH53_2800 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.940 |
| apt | guaA | CH53_2897 | CH53_620 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.990 |
| apt | guaC | CH53_2897 | CH53_1004 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.925 |
| apt | hpt | CH53_2897 | CH53_983 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | HGPRTase: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.928 |
| apt | purA | CH53_2897 | CH53_1333 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.530 |
| apt | purH | CH53_2897 | CH53_2111 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | purH: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.960 |
| apt | surE | CH53_2897 | CH53_927 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 5'/3'-nucleotidase SurE; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. | 0.920 |
| gmk | CH53_1552 | CH53_1828 | CH53_1552 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | 0.900 |