STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lsrKAutoinducer 2 kinase LsrK; Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position. (526 aa)    
Predicted Functional Partners:
lsrG
Autoinducer 2-degrading protein lsrG; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5- phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5- phosphonooxypentane-2,4-dione (P-HPD); Belongs to the LsrG family.
 
 
 0.931
lsrR
Transcriptional regulator lsrR.
 
  
 0.927
lsrF
Hypothetical protein; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5- phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA; Belongs to the DeoC/FbaB aldolase family.
 
  
 0.881
lsrB
Autoinducer 2-binding protein lsrB.
 
  
 0.854
lsrD_2
Branched-chain amino acid transport system / permease component family protein; Belongs to the binding-protein-dependent transport system permease family.
 
  
 0.755
ccmA-2
ccmA: heme ABC exporter, ATP-binding protein CcmA.
 
  
 0.696
lsrC
Branched-chain amino acid transport system / permease component family protein; Belongs to the binding-protein-dependent transport system permease family.
  
  
 0.678
ptsH
Phosphocarrier protein HPr.
    
 
 0.632
rhaM
L-rhamnose mutarotase; Involved in the anomeric conversion of L-rhamnose.
  
  
 0.627
xylF
xylF: D-xylose ABC transporter, D-xylose-binding protein.
     
 0.564
Your Current Organism:
Yersinia intermedia
NCBI taxonomy Id: 631
Other names: ATCC 29909, CCUG 11292, CIP 80.28, DSM 18517, JCM 7579, NCTC 11469, Y. intermedia, strain 3953, strain Bottone 48, strain Chester 48
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