| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| apt | gmk | CH53_2897 | CH53_1828 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.953 |
| apt | gpt | CH53_2897 | CH53_2800 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.940 |
| apt | guaA | CH53_2897 | CH53_620 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.990 |
| apt | guaC | CH53_2897 | CH53_1004 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.925 |
| apt | hpt | CH53_2897 | CH53_983 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | HGPRTase: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.928 |
| gmk | apt | CH53_1828 | CH53_2897 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.953 |
| gmk | gpt | CH53_1828 | CH53_2800 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.953 |
| gmk | guaA | CH53_1828 | CH53_620 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.969 |
| gmk | guaC | CH53_1828 | CH53_1004 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.921 |
| gmk | hpt | CH53_1828 | CH53_983 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | HGPRTase: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.940 |
| gmk | ndk | CH53_1828 | CH53_633 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.933 |
| gmk | pyk | CH53_1828 | CH53_3809 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Pyruv_kin: pyruvate kinase; Belongs to the pyruvate kinase family. | 0.926 |
| gmk | pyk-2 | CH53_1828 | CH53_4108 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Pyruv_kin: pyruvate kinase; Belongs to the pyruvate kinase family. | 0.930 |
| gmk | rpoZ | CH53_1828 | CH53_1827 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.968 |
| gmk | spoT | CH53_1828 | CH53_1826 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Bifunctional (p)ppGpp synthase/hydrolase SpoT; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.965 |
| gpt | apt | CH53_2800 | CH53_2897 | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.940 |
| gpt | gmk | CH53_2800 | CH53_1828 | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.953 |
| gpt | guaA | CH53_2800 | CH53_620 | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.990 |
| gpt | guaC | CH53_2800 | CH53_1004 | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.923 |
| gpt | hpt | CH53_2800 | CH53_983 | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | HGPRTase: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.926 |