| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| carA | carB | CH53_1066 | CH53_1065 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | 0.999 |
| carA | fre | CH53_1066 | CH53_2069 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | NAD(P)H-flavin reductase. | 0.900 |
| carA | pyrB | CH53_1066 | CH53_2237 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Asp_carb_tr: aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
| carA | pyrD | CH53_1066 | CH53_128 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.941 |
| carA | pyrE | CH53_1066 | CH53_1853 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.922 |
| carA | pyrF | CH53_1066 | CH53_3918 | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.913 |
| carB | carA | CH53_1065 | CH53_1066 | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | 0.999 |
| carB | fre | CH53_1065 | CH53_2069 | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | NAD(P)H-flavin reductase. | 0.920 |
| carB | pyrB | CH53_1065 | CH53_2237 | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | Asp_carb_tr: aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
| carB | pyrD | CH53_1065 | CH53_128 | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.970 |
| carB | pyrE | CH53_1065 | CH53_1853 | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.953 |
| carB | pyrF | CH53_1065 | CH53_3918 | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.952 |
| fre | carA | CH53_2069 | CH53_1066 | NAD(P)H-flavin reductase. | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. | 0.900 |
| fre | carB | CH53_2069 | CH53_1065 | NAD(P)H-flavin reductase. | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | 0.920 |
| fre | pyrB | CH53_2069 | CH53_2237 | NAD(P)H-flavin reductase. | Asp_carb_tr: aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.915 |
| fre | pyrD | CH53_2069 | CH53_128 | NAD(P)H-flavin reductase. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.979 |
| fre | pyrE | CH53_2069 | CH53_1853 | NAD(P)H-flavin reductase. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.917 |
| fre | pyrF | CH53_2069 | CH53_3918 | NAD(P)H-flavin reductase. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.914 |
| fre | ribE | CH53_2069 | CH53_4103 | NAD(P)H-flavin reductase. | ribE: riboflavin synthase, alpha subunit. | 0.903 |
| fre | ribF | CH53_2069 | CH53_1072 | NAD(P)H-flavin reductase. | ribF: riboflavin biosynthesis protein RibF; Belongs to the ribF family. | 0.911 |