aceK protein (Yersinia intermedia) - STRING interaction network

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aceK

Isocitrate dehydrogenase kinase/phosphatase family protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (575 aa)

Predicted Functional Partners:

aceA

0.966

icd

0.911

aceB

0.803

mglC

0.410

Your Current Organism:

Yersinia intermedia

NCBI taxonomy Id: 631
Other names: ATCC 29909, CCUG 11292, CIP 80.28, DSM 18517, JCM 7579, NCTC 11469, Y. intermedia, strain 3953, strain Bottone 48, strain Chester 48

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
aceA	aceB	CH53_2122	CH53_2121	Isocit_lyase: isocitrate lyase.	malate_syn_A: malate synthase A.	0.999
aceA	aceK	CH53_2122	CH53_2123	Isocit_lyase: isocitrate lyase.	Isocitrate dehydrogenase kinase/phosphatase family protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.	0.966
aceA	icd	CH53_2122	CH53_4399	Isocit_lyase: isocitrate lyase.	Prok_nadp_idh: isocitrate dehydrogenase, NADP-dependent.	0.550
aceB	aceA	CH53_2121	CH53_2122	malate_syn_A: malate synthase A.	Isocit_lyase: isocitrate lyase.	0.999
aceB	aceK	CH53_2121	CH53_2123	malate_syn_A: malate synthase A.	Isocitrate dehydrogenase kinase/phosphatase family protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.	0.803
aceB	icd	CH53_2121	CH53_4399	malate_syn_A: malate synthase A.	Prok_nadp_idh: isocitrate dehydrogenase, NADP-dependent.	0.615
aceK	aceA	CH53_2123	CH53_2122	Isocitrate dehydrogenase kinase/phosphatase family protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.	Isocit_lyase: isocitrate lyase.	0.966
aceK	aceB	CH53_2123	CH53_2121	Isocitrate dehydrogenase kinase/phosphatase family protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.	malate_syn_A: malate synthase A.	0.803
aceK	icd	CH53_2123	CH53_4399	Isocitrate dehydrogenase kinase/phosphatase family protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.	Prok_nadp_idh: isocitrate dehydrogenase, NADP-dependent.	0.911
aceK	mglC	CH53_2123	CH53_3272	Isocitrate dehydrogenase kinase/phosphatase family protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.	Branched-chain amino acid transport system / permease component family protein; Belongs to the binding-protein-dependent transport system permease family.	0.410
icd	aceA	CH53_4399	CH53_2122	Prok_nadp_idh: isocitrate dehydrogenase, NADP-dependent.	Isocit_lyase: isocitrate lyase.	0.550
icd	aceB	CH53_4399	CH53_2121	Prok_nadp_idh: isocitrate dehydrogenase, NADP-dependent.	malate_syn_A: malate synthase A.	0.615
icd	aceK	CH53_4399	CH53_2123	Prok_nadp_idh: isocitrate dehydrogenase, NADP-dependent.	Isocitrate dehydrogenase kinase/phosphatase family protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.	0.911
mglC	aceK	CH53_3272	CH53_2123	Branched-chain amino acid transport system / permease component family protein; Belongs to the binding-protein-dependent transport system permease family.	Isocitrate dehydrogenase kinase/phosphatase family protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.	0.410

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