STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metHMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1231 aa)    
Predicted Functional Partners:
metF
Fadh2: methylenetetrahydrofolate reductase [NAD(P)H]; Belongs to the methylenetetrahydrofolate reductase family.
 
 
 0.997
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.979
metB
O-succinylhomoserine (thiol)-lyase; Cystathionine gamma-lyase-like protein; O_succ_thio_ly: O-succinylhomoserine (thiol)-lyase.
  
 
 0.972
metB_2
cys/Met metabolism PLP-dependent enzyme family protein.
  
 
 0.972
metC
cysta_beta_ly_B: cystathionine beta-lyase.
  
 
 0.972
metB-2
O-succinylhomoserine (thiol)-lyase; Cystathionine gamma-lyase-like protein.
  
 
 0.972
thrA
Asp_kinase: aspartate kinase domain protein; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.957
metL
Homoserine dehydrogenase, NAD binding domain protein; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.957
gcvT
Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.
  
 
 0.956
fhs
Formate--tetrahydrofolate ligase family protein; Belongs to the formate--tetrahydrofolate ligase family.
  
 
 0.953
Your Current Organism:
Yersinia intermedia
NCBI taxonomy Id: 631
Other names: ATCC 29909, CCUG 11292, CIP 80.28, DSM 18517, JCM 7579, NCTC 11469, Y. intermedia, strain 3953, strain Bottone 48, strain Chester 48
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