| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CH53_267 | yejK | CH53_267 | CH53_269 | DEAD/DEAH box helicase family protein. | 37-kD nucleoid-associated bacterial family protein. | 0.530 |
| CH53_267 | yejM | CH53_267 | CH53_271 | DEAD/DEAH box helicase family protein. | Type I phosphodiesterase / nucleotide pyrophosphatase family protein. | 0.461 |
| astE | yejK | CH53_3737 | CH53_269 | Succinylglutamate desuccinylase; Transforms N(2)-succinylglutamate into succinate and glutamate; Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily. | 37-kD nucleoid-associated bacterial family protein. | 0.478 |
| matP | seqA | CH53_116 | CH53_3118 | Organizer of macrodomain of Terminus of chromosome family protein; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain. | Protein seqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.419 |
| matP | yejK | CH53_116 | CH53_269 | Organizer of macrodomain of Terminus of chromosome family protein; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain. | 37-kD nucleoid-associated bacterial family protein. | 0.487 |
| matP | yejM | CH53_116 | CH53_271 | Organizer of macrodomain of Terminus of chromosome family protein; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain. | Type I phosphodiesterase / nucleotide pyrophosphatase family protein. | 0.652 |
| matP | yfbV | CH53_116 | CH53_390 | Organizer of macrodomain of Terminus of chromosome family protein; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain. | Hypothetical protein. | 0.602 |
| metJ | seqA | CH53_1906 | CH53_3118 | Met Apo-repressor, MetJ family protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | Protein seqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.752 |
| metJ | yejK | CH53_1906 | CH53_269 | Met Apo-repressor, MetJ family protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | 37-kD nucleoid-associated bacterial family protein. | 0.485 |
| metJ | yejL | CH53_1906 | CH53_270 | Met Apo-repressor, MetJ family protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | Hypothetical protein; Belongs to the UPF0352 family. | 0.600 |
| metJ | yfbV | CH53_1906 | CH53_390 | Met Apo-repressor, MetJ family protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | Hypothetical protein. | 0.724 |
| metJ | yifE | CH53_1906 | CH53_1948 | Met Apo-repressor, MetJ family protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | Hypothetical protein. | 0.712 |
| rlmM | yejK | CH53_2708 | CH53_269 | ftsJ-like methyltransferase family protein; Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily. | 37-kD nucleoid-associated bacterial family protein. | 0.564 |
| seqA | matP | CH53_3118 | CH53_116 | Protein seqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | Organizer of macrodomain of Terminus of chromosome family protein; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain. | 0.419 |
| seqA | metJ | CH53_3118 | CH53_1906 | Protein seqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | Met Apo-repressor, MetJ family protein; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. | 0.752 |
| seqA | yejK | CH53_3118 | CH53_269 | Protein seqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 37-kD nucleoid-associated bacterial family protein. | 0.502 |
| seqA | yejL | CH53_3118 | CH53_270 | Protein seqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | Hypothetical protein; Belongs to the UPF0352 family. | 0.773 |
| seqA | yejM | CH53_3118 | CH53_271 | Protein seqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | Type I phosphodiesterase / nucleotide pyrophosphatase family protein. | 0.462 |
| seqA | yfbV | CH53_3118 | CH53_390 | Protein seqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | Hypothetical protein. | 0.753 |
| seqA | yifE | CH53_3118 | CH53_1948 | Protein seqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | Hypothetical protein. | 0.560 |