| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cdh | cdsA | CH53_1617 | CH53_2726 | CDP-diacylglycerol pyrophosphatase family protein. | Phosphatidate cytidylyltransferase; Belongs to the CDS family. | 0.908 |
| cdh | pgsA | CH53_1617 | CH53_3622 | CDP-diacylglycerol pyrophosphatase family protein. | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.911 |
| cdh | pssA | CH53_1617 | CH53_2759 | CDP-diacylglycerol pyrophosphatase family protein. | CDP-diacylglycerol--serine O-phosphatidyltransferase. | 0.918 |
| cdsA | cdh | CH53_2726 | CH53_1617 | Phosphatidate cytidylyltransferase; Belongs to the CDS family. | CDP-diacylglycerol pyrophosphatase family protein. | 0.908 |
| cdsA | pgsA | CH53_2726 | CH53_3622 | Phosphatidate cytidylyltransferase; Belongs to the CDS family. | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.961 |
| cdsA | psd | CH53_2726 | CH53_1350 | Phosphatidate cytidylyltransferase; Belongs to the CDS family. | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | 0.573 |
| cdsA | pssA | CH53_2726 | CH53_2759 | Phosphatidate cytidylyltransferase; Belongs to the CDS family. | CDP-diacylglycerol--serine O-phosphatidyltransferase. | 0.938 |
| glyA | pssA | CH53_654 | CH53_2759 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | CDP-diacylglycerol--serine O-phosphatidyltransferase. | 0.937 |
| glyA | serB | CH53_654 | CH53_1112 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | serB: phosphoserine phosphatase SerB. | 0.940 |
| glyA | trpA | CH53_654 | CH53_3894 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.935 |
| glyA | trpB | CH53_654 | CH53_3895 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.932 |
| glyA | uptG | CH53_654 | CH53_217 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | CBS domain protein. | 0.947 |
| pgsA | cdh | CH53_3622 | CH53_1617 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | CDP-diacylglycerol pyrophosphatase family protein. | 0.911 |
| pgsA | cdsA | CH53_3622 | CH53_2726 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphatidate cytidylyltransferase; Belongs to the CDS family. | 0.961 |
| pgsA | psd | CH53_3622 | CH53_1350 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | 0.781 |
| pgsA | pssA | CH53_3622 | CH53_2759 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | CDP-diacylglycerol--serine O-phosphatidyltransferase. | 0.944 |
| pldA | psd | CH53_2008 | CH53_1350 | Phospholipase A1; Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Belongs to the phospholipase A1 family. | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | 0.913 |
| pldA | pssA | CH53_2008 | CH53_2759 | Phospholipase A1; Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Belongs to the phospholipase A1 family. | CDP-diacylglycerol--serine O-phosphatidyltransferase. | 0.908 |
| psd | cdsA | CH53_1350 | CH53_2726 | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | Phosphatidate cytidylyltransferase; Belongs to the CDS family. | 0.573 |
| psd | pgsA | CH53_1350 | CH53_3622 | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.781 |