| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| allB | allC | CH53_66 | CH53_62 | Allantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. | allC: allantoate amidohydrolase. | 0.986 |
| allB | allD | CH53_66 | CH53_61 | Allantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. | allD: ureidoglycolate dehydrogenase; Belongs to the LDH2/MDH2 oxidoreductase family. | 0.682 |
| allB | hyuC | CH53_66 | CH53_2772 | Allantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. | Hydantase: amidase, hydantoinase/carbamoylase family protein. | 0.975 |
| allB | pucG | CH53_66 | CH53_2771 | Allantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. | Putative ureidoglycine-glyoxylate aminotransferase. | 0.676 |
| allB | ylbA | CH53_66 | CH53_63 | Allantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. | Hypothetical protein. | 0.825 |
| allC | allB | CH53_62 | CH53_66 | allC: allantoate amidohydrolase. | Allantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. | 0.986 |
| allC | allD | CH53_62 | CH53_61 | allC: allantoate amidohydrolase. | allD: ureidoglycolate dehydrogenase; Belongs to the LDH2/MDH2 oxidoreductase family. | 0.852 |
| allC | hyuC | CH53_62 | CH53_2772 | allC: allantoate amidohydrolase. | Hydantase: amidase, hydantoinase/carbamoylase family protein. | 0.922 |
| allC | pucG | CH53_62 | CH53_2771 | allC: allantoate amidohydrolase. | Putative ureidoglycine-glyoxylate aminotransferase. | 0.963 |
| allC | ylbA | CH53_62 | CH53_63 | allC: allantoate amidohydrolase. | Hypothetical protein. | 0.991 |
| allD | allB | CH53_61 | CH53_66 | allD: ureidoglycolate dehydrogenase; Belongs to the LDH2/MDH2 oxidoreductase family. | Allantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. | 0.682 |
| allD | allC | CH53_61 | CH53_62 | allD: ureidoglycolate dehydrogenase; Belongs to the LDH2/MDH2 oxidoreductase family. | allC: allantoate amidohydrolase. | 0.852 |
| allD | hyuC | CH53_61 | CH53_2772 | allD: ureidoglycolate dehydrogenase; Belongs to the LDH2/MDH2 oxidoreductase family. | Hydantase: amidase, hydantoinase/carbamoylase family protein. | 0.421 |
| allD | pucG | CH53_61 | CH53_2771 | allD: ureidoglycolate dehydrogenase; Belongs to the LDH2/MDH2 oxidoreductase family. | Putative ureidoglycine-glyoxylate aminotransferase. | 0.913 |
| allD | ylbA | CH53_61 | CH53_63 | allD: ureidoglycolate dehydrogenase; Belongs to the LDH2/MDH2 oxidoreductase family. | Hypothetical protein. | 0.984 |
| gcvP | glyA | CH53_2622 | CH53_654 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.995 |
| gcvP | kbl | CH53_2622 | CH53_1868 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.946 |
| gcvP | ltaE | CH53_2622 | CH53_187 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Low specificity L-threonine aldolase. | 0.951 |
| gcvP | pucG | CH53_2622 | CH53_2771 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Putative ureidoglycine-glyoxylate aminotransferase. | 0.881 |
| glyA | gcvP | CH53_654 | CH53_2622 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.995 |