| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cobB-2 | nadD | CH53_4410 | CH53_3067 | Sir2 family protein; Belongs to the sirtuin family. Class III subfamily. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.932 |
| cobB-2 | nadE | CH53_4410 | CH53_663 | Sir2 family protein; Belongs to the sirtuin family. Class III subfamily. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.950 |
| cobB-2 | nadR | CH53_4410 | CH53_1110 | Sir2 family protein; Belongs to the sirtuin family. Class III subfamily. | Trifunctional NAD biosynthesis/regulator protein NadR. | 0.995 |
| cobB-2 | nudC | CH53_4410 | CH53_2104 | Sir2 family protein; Belongs to the sirtuin family. Class III subfamily. | NADH pyrophosphatase-like rudimentary NUDIX domain protein; Belongs to the Nudix hydrolase family. NudC subfamily. | 0.908 |
| cobB-2 | pntA | CH53_4410 | CH53_4026 | Sir2 family protein; Belongs to the sirtuin family. Class III subfamily. | NAD(P)(+) transhydrogenase (AB-specific), alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | 0.904 |
| cobB-2 | ppnK | CH53_4410 | CH53_696 | Sir2 family protein; Belongs to the sirtuin family. Class III subfamily. | ATP-NAD kinase family protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.917 |
| nadC | nadD | CH53_1000 | CH53_3067 | nadC: nicotinate-nucleotide diphosphorylase; Belongs to the NadC/ModD family. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.954 |
| nadC | nadE | CH53_1000 | CH53_663 | nadC: nicotinate-nucleotide diphosphorylase; Belongs to the NadC/ModD family. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.652 |
| nadC | nadR | CH53_1000 | CH53_1110 | nadC: nicotinate-nucleotide diphosphorylase; Belongs to the NadC/ModD family. | Trifunctional NAD biosynthesis/regulator protein NadR. | 0.955 |
| nadC | nudC | CH53_1000 | CH53_2104 | nadC: nicotinate-nucleotide diphosphorylase; Belongs to the NadC/ModD family. | NADH pyrophosphatase-like rudimentary NUDIX domain protein; Belongs to the Nudix hydrolase family. NudC subfamily. | 0.900 |
| nadC | pncB | CH53_1000 | CH53_130 | nadC: nicotinate-nucleotide diphosphorylase; Belongs to the NadC/ModD family. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.975 |
| nadC | ushA | CH53_1000 | CH53_2918 | nadC: nicotinate-nucleotide diphosphorylase; Belongs to the NadC/ModD family. | Protein UshA; Belongs to the 5'-nucleotidase family. | 0.900 |
| nadC | ygaD | CH53_1000 | CH53_824 | nadC: nicotinate-nucleotide diphosphorylase; Belongs to the NadC/ModD family. | Protein YgaD; Belongs to the CinA family. | 0.928 |
| nadD | cobB-2 | CH53_3067 | CH53_4410 | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Sir2 family protein; Belongs to the sirtuin family. Class III subfamily. | 0.932 |
| nadD | nadC | CH53_3067 | CH53_1000 | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | nadC: nicotinate-nucleotide diphosphorylase; Belongs to the NadC/ModD family. | 0.954 |
| nadD | nadE | CH53_3067 | CH53_663 | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.965 |
| nadD | nadR | CH53_3067 | CH53_1110 | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Trifunctional NAD biosynthesis/regulator protein NadR. | 0.955 |
| nadD | nudC | CH53_3067 | CH53_2104 | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | NADH pyrophosphatase-like rudimentary NUDIX domain protein; Belongs to the Nudix hydrolase family. NudC subfamily. | 0.907 |
| nadD | pncB | CH53_3067 | CH53_130 | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.955 |
| nadD | pntA | CH53_3067 | CH53_4026 | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | NAD(P)(+) transhydrogenase (AB-specific), alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | 0.904 |