| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| appA | fre | CH53_3517 | CH53_2069 | Periplasmic AppA protein. | NAD(P)H-flavin reductase. | 0.900 |
| appA | ribE | CH53_3517 | CH53_4103 | Periplasmic AppA protein. | ribE: riboflavin synthase, alpha subunit. | 0.900 |
| appA | ribF | CH53_3517 | CH53_1072 | Periplasmic AppA protein. | ribF: riboflavin biosynthesis protein RibF; Belongs to the ribF family. | 0.900 |
| appA | ybjI | CH53_3517 | CH53_3678 | Periplasmic AppA protein. | Phosphatase YbjI. | 0.900 |
| appA | yfnB | CH53_3517 | CH53_1999 | Periplasmic AppA protein. | HAD-SF-IA-v1: HAD hydrolase, IA, variant 1 family protein. | 0.900 |
| cof_2 | ybjI | CH53_2013 | CH53_3678 | HAD-SF-IIB: HAD hydrolase, IIB family protein. | Phosphatase YbjI. | 0.683 |
| cpdB | ybjI | CH53_1318 | CH53_3678 | cycNucDiestase: 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Belongs to the 5'-nucleotidase family. | Phosphatase YbjI. | 0.620 |
| cpdB | yjjG | CH53_1318 | CH53_4009 | cycNucDiestase: 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Belongs to the 5'-nucleotidase family. | yjjG/YfnB: noncanonical pyrimidine nucleotidase, YjjG family. | 0.966 |
| fre | appA | CH53_2069 | CH53_3517 | NAD(P)H-flavin reductase. | Periplasmic AppA protein. | 0.900 |
| fre | ribE | CH53_2069 | CH53_4103 | NAD(P)H-flavin reductase. | ribE: riboflavin synthase, alpha subunit. | 0.903 |
| fre | ribF | CH53_2069 | CH53_1072 | NAD(P)H-flavin reductase. | ribF: riboflavin biosynthesis protein RibF; Belongs to the ribF family. | 0.911 |
| fre | ybjI | CH53_2069 | CH53_3678 | NAD(P)H-flavin reductase. | Phosphatase YbjI. | 0.901 |
| fre | yfnB | CH53_2069 | CH53_1999 | NAD(P)H-flavin reductase. | HAD-SF-IA-v1: HAD hydrolase, IA, variant 1 family protein. | 0.900 |
| ribD | ribE | CH53_2838 | CH53_4103 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | ribE: riboflavin synthase, alpha subunit. | 0.999 |
| ribD | ribF | CH53_2838 | CH53_1072 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | ribF: riboflavin biosynthesis protein RibF; Belongs to the ribF family. | 0.742 |
| ribD | ribH | CH53_2838 | CH53_2839 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.995 |
| ribD | ybjI | CH53_2838 | CH53_3678 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Phosphatase YbjI. | 0.916 |
| ribD | yfnB | CH53_2838 | CH53_1999 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | HAD-SF-IA-v1: HAD hydrolase, IA, variant 1 family protein. | 0.932 |
| ribE | appA | CH53_4103 | CH53_3517 | ribE: riboflavin synthase, alpha subunit. | Periplasmic AppA protein. | 0.900 |
| ribE | fre | CH53_4103 | CH53_2069 | ribE: riboflavin synthase, alpha subunit. | NAD(P)H-flavin reductase. | 0.903 |